Salivary Gland Volume Predicts Malnutrition in Irradiated Head and Neck Cancer Patients: A Prospective Analysis.

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL In vivo Pub Date : 2024-11-01 DOI:10.21873/invivo.13759
Anna Finger, Franziska Greinert, Maximilian Grohmann, Niloufar Seyedi, Rouzbeh Zohri, Andreas Krüll, Cordula Petersen, Oksana Zemkova, Christian Ziemann, Kerstin Ramke, Elisa Werner, Claudia Ditz, Jan Leppert, Lorenz Hahn, Dirk Rades, Anastassia Löser
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Abstract

Background/aim: Xerostomia following (chemo-) radiotherapy (CRT) is common in head and neck (HNC) patients. This prospective study focused on investigating the link between salivary gland function and the onset of malnutrition in HNC patients.

Patients and methods: Between 2018 and 2020, 61 HNC patients scheduled for curative CRT were prospectively recruited. Nutritional status was assessed by bioelectrical impedance analysis (BIA) and xerostomia was evaluated based on the Common Terminology Criteria for Adverse Events, (CTCAE). Patient-reported outcomes for xerostomia-related symptoms, such as "dry mouth" and "sticky saliva", were also collected. Data were assessed at the beginning of therapy, during treatment, at the end of treatment, and during follow-up. Organs at risk were contoured including the submandibular and parotid glands. Dose-volume parameters were extracted for the mean Dose (Dmean), V15 Gy, V30Gy and V45Gy.

Results: No correlation was found between the dosimetric parameters [Dmean, V15Gy (%), V30Gy (%) and V45Gy (%)] and the occurrence of malnutrition [defined by a fat-free mass index (FFMI) <15 kg/m2 (♀) and <17 kg/m2 (♂) kg/m2 and/or body-mass index (BMI) <18.5 kg/m2] at any of the three time points tested. However, the volume of the parotid glands prior to therapy appeared to be related to the development of malnutrition. This effect was not observed with the submandibular glands. A cumulative parotid gland volume of 55.3 cm3 was identified as the threshold for malnutrition at the second follow-up examination.

Conclusion: Although none of the dosimetric factors were associated with the development of malnutrition, the baseline parotid gland volume emerged as an independent predictor of malnutrition in head and neck cancer patients with xerostomia.

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唾液腺体积可预测头颈癌放射治疗患者的营养不良情况:前瞻性分析
背景/目的:头颈部(HNC)患者在接受(化)放疗(CRT)后出现口腔干燥症很常见。这项前瞻性研究的重点是调查唾液腺功能与HNC患者营养不良发病之间的联系:2018年至2020年间,前瞻性招募了61名计划接受治愈性CRT的HNC患者。通过生物电阻抗分析(BIA)评估营养状况,并根据不良事件通用术语标准(CTCAE)评估口腔干燥症。此外,还收集了 "口干 "和 "唾液粘稠 "等口腔干燥相关症状的患者报告结果。数据在治疗开始、治疗期间、治疗结束和随访期间进行评估。对有风险的器官(包括颌下腺和腮腺)进行了轮廓分析。提取了平均剂量(Dmean)、V15Gy、V30Gy 和 V45Gy 的剂量-体积参数:在测试的三个时间点中,没有发现剂量参数[Dmean、V15Gy (%)、V30Gy (%)和V45Gy (%)]与营养不良发生率[定义为无脂肪质量指数(FFMI)2 (♀)和2 (♂)kg/m2和/或体重指数(BMI)2]之间存在相关性。然而,治疗前的腮腺体积似乎与营养不良的发展有关。颌下腺则没有观察到这种影响。在第二次随访检查时,腮腺累积体积为 55.3 立方厘米被确定为营养不良的临界值:结论:虽然所有剂量测量因素都与营养不良的发生无关,但基线腮腺体积是预测患有口腔异味的头颈部癌症患者营养不良的一个独立因素。
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来源期刊
In vivo
In vivo 医学-医学:研究与实验
CiteScore
4.20
自引率
4.30%
发文量
330
审稿时长
3-8 weeks
期刊介绍: IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
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