Gastric cancer and associated pathogens: is there any association in Moroccan region?

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES Japanese journal of infectious diseases Pub Date : 2024-10-31 DOI:10.7883/yoken.JJID.2024.147

Samia Alaoui Boukhris, Mounia El Khadir, Safae Karim, Tiatou Souho, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani

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Abstract

Helicobacter pylori, Epstein-Barr virus and human papillomavirus are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in Moroccan population. For this, a retrospective study has been conducted on participants attending the gastroenterology department of Hassan II University Hospital of Fez. A total of 279 participants were enrolled. H. pylori, EBV and HPV were detected and genotyped by PCR. In results, a significant association has been established between H. pylori, EBV and gastric cancer. 93.4% and 43.3% of gastric cancer cases are related to H. pylori and EBV respectively (p≤0.01). H. pylori-EBV co-infection is responsible of 31.6% of gastric cancer cases (p<0.01). Correlation between pathogens genotypes and gastric cancer shows 54.6% of GC EBV positives are carrying the 30 bp deletion in LMP1gene, while 16% of gastric cancers cases are carrying high-risk genotypes of HPV (p=0.21). The obtained results highlight the possible role of co-infection in gastric cancer development.

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胃癌与相关病原体：摩洛哥地区是否存在关联？

幽门螺杆菌、Epstein-Barr 病毒和人类乳头瘤病毒是与各种人类癌症相关的三种病原体。本研究旨在调查这些病原体在摩洛哥人胃癌中的作用。为此，我们对在非斯哈桑二世大学医院消化科就诊的患者进行了回顾性研究。共有 279 人参加了这项研究。研究人员通过 PCR 对幽门螺杆菌、EBV 和 HPV 进行了检测和基因分型。结果显示，幽门螺杆菌、EBV 和胃癌之间存在明显的关联。93.4%和43.3%的胃癌病例分别与幽门螺杆菌和EBV有关（P≤0.01）。31.6%的胃癌病例与幽门螺杆菌和 EBV 共同感染有关（p

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来源期刊

Japanese journal of infectious diseases 医学-传染病学

CiteScore

4.50

自引率

4.50%

发文量

172

审稿时长

2 months

期刊介绍： Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.