Respiratory Carriage of Methicillin-Resistant Staphylococcus aureus-Encoding Gene in Hajj Pilgrims.

IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Epidemiology and Global Health Pub Date : 2024-10-29 DOI:10.1007/s44197-024-00322-5
Thi Loi Dao, Van Thuan Hoang, Philippe Gautret
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Abstract

Objectives: To assess the carriage of methicillin-resistant Staphylococcus aureus-encoding genes (MRSA) among French Hajj pilgrim cohorts.

Methods: A prospective cohort study was conducted on pilgrims from Marseille during the 2014 to 2018 Hajj. Respiratory samples were collected before and after the pilgrimage. S. aureus and then MRSA-encoding genes were identified using real-time PCR.

Results: A total of 606 pilgrims were included with a sex ratio of 1:1.3 with a median age of 61 years (interquartile = 56-66 years, range = 21-88 years). A total of 511/606 (84.3%) pilgrims presented at least one respiratory symptom during their pilgrimage. Cough was the most frequent symptom occurring in 76.2% of pilgrims, followed by sore throat (57.6%), rhinitis (54.6%), and voice failure (36.3%). 87 (14.4%) were positive with S. aureus before travelling. On return, 130/606 (21.4%) participants were positive. The acquisition rate of S. aureus was 13.0% (79/606). The prevalence of MRSA pre- and post-travel and acquisition rate was 4.1% (25/606), 10.6% (62/606), and 8.2% (50/606), respectively. All MRSA were positive with mecA gene. No case was positive with mecC.

Conclusion: Our study highlights the importance of surveillance and infection control measures during mass gatherings such as the Hajj to mitigate the spread of infectious pathogens, including antimicrobial-resistant bacteria like MRSA. Further research is warranted to elucidate the specific factors contributing to S. aureus and MRSA transmission during the pilgrimage and to inform targeted interventions aimed at reducing the burden of MRSA infection among pilgrims.

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朝觐者呼吸道携带的耐甲氧西林金黄色葡萄球菌编码基因
目的评估法国朝觐者队列中耐甲氧西林金黄色葡萄球菌编码基因(MRSA)的携带情况:对 2014 年至 2018 年朝觐期间来自马赛的朝圣者进行了前瞻性队列研究。朝觐前后采集了呼吸道样本。使用实时 PCR 鉴定金黄色葡萄球菌和 MRSA 编码基因:结果:共有 606 名朝圣者,男女比例为 1:1.3,中位年龄为 61 岁(四分位间 = 56-66 岁,范围 = 21-88 岁)。朝圣者中有 511/606 人(84.3%)在朝圣期间至少出现过一种呼吸道症状。76.2%的朝圣者最常见的症状是咳嗽,其次是喉咙痛(57.6%)、鼻炎(54.6%)和失声(36.3%)。87人(14.4%)在旅行前对金黄色葡萄球菌呈阳性反应。回国后,每 606 人中有 130 人(21.4%)对金黄色葡萄球菌呈阳性反应。金黄色葡萄球菌感染率为 13.0%(79/606)。旅行前后的 MRSA 感染率和感染率分别为 4.1%(25/606)、10.6%(62/606)和 8.2%(50/606)。所有 MRSA 的 mecA 基因均呈阳性。结论:我们的研究强调了在朝觐等大规模集会期间采取监控和感染控制措施以减少传染病病原体(包括 MRSA 等耐抗菌素细菌)传播的重要性。有必要开展进一步研究,以阐明朝圣期间导致金黄色葡萄球菌和 MRSA 传播的具体因素,并为旨在减轻朝圣者中 MRSA 感染负担的针对性干预措施提供信息。
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来源期刊
CiteScore
10.70
自引率
1.40%
发文量
57
审稿时长
19 weeks
期刊介绍: The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
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