fNIRS Study of Brain Activation during Multiple Motor Control Conditions in Younger and Older Adults.

IF 2.5 4区医学 Q3 NEUROSCIENCES Journal of integrative neuroscience Pub Date : 2024-10-12 DOI:10.31083/j.jin2310189

Duoduo Yu, Conghui Wei, Zhen Yuan, Jun Luo

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Abstract

Background: Evidence suggests that aging contributes to decreased cerebral blood flow and brain oxyhemoglobin (HbO₂) in the association cortices during rest. However, the influence of aging on functional brain activation is still controversial. The objective of this study was to investigate the age-related dependence of HbO₂ across distinct motor control conditions in both primary and association cortices.

Methods: Using functional near-infrared spectroscopy (fNIRS), this study assessed HbO₂ level changes within the primary somatosensory cortex (PSC), primary motor cortex (PMC), supplementary motor cortex (SMC), prefrontal cortex (PFC) and dorsolateral prefrontal cortex (DLPFC) under various motor control conditions. Analysis examined changes in the concentration of HbO₂ measured by fNIRS during rest, motor execution (ME), motor passivity (MP) and motor imagery (MI) with elbow flexion in 30 younger (21.5 ± 1.17 years old) and 30 older (60.9 ± 0.79 years old) adults.

Results: During motor execution HbO₂ was higher in younger adults than older adults in bilateral PMC, bilateral PFC, left PSC, left SMC and left DLPFC (p < 0.05). During motor passivity, HbO₂ was higher in younger adults than older adults in bilateral PMC, left PSC and left SMC (p < 0.05). During motor imagery, HbO₂ was higher in younger adults than older adults in bilateral PFC and bilateral DLPFC (p < 0.05).

Conclusion: This study provided evidence that HbO₂ levels are different in the primary and association cortices during different motor control conditions in young and old adults and that HbO₂ levels in different brain regions under different motor control conditions can be influenced by age.

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对年轻人和老年人在多种运动控制条件下大脑激活情况的 fNIRS 研究。

背景：有证据表明，衰老会导致联想皮层在休息时脑血流量和脑氧血红蛋白（HbO2）减少。然而，衰老对大脑功能激活的影响仍存在争议。本研究旨在调查初级皮层和联想皮层在不同运动控制条件下与年龄相关的 HbO2 依赖性：本研究使用功能性近红外光谱（fNIRS）评估了各种运动控制条件下初级体感皮层（PSC）、初级运动皮层（PMC）、辅助运动皮层（SMC）、前额叶皮层（PFC）和背外侧前额叶皮层（DLPFC）中的 HbO2 水平变化。分析研究了 30 名年轻（21.5 ± 1.17 岁）和 30 名年长（60.9 ± 0.79 岁）成年人在休息、运动执行（ME）、运动被动（MP）和肘关节屈曲时运动想象（MI）过程中通过 fNIRS 测量的 HbO2 浓度变化：在运动执行过程中，年轻人双侧 PMC、双侧 PFC、左侧 PSC、左侧 SMC 和左侧 DLPFC 中的 HbO2 均高于老年人（P < 0.05）。在运动被动过程中，年轻成人双侧 PMC、左侧 PSC 和左侧 SMC 的 HbO2 均高于老年人（p < 0.05）。在运动想象过程中，年轻成人双侧 PFC 和双侧 DLPFC 中的 HbO2 高于老年人（P < 0.05）：本研究提供的证据表明，在不同的运动控制条件下，年轻人和老年人的初级皮层和联想皮层的 HbO2 水平是不同的，而且在不同的运动控制条件下，不同脑区的 HbO2 水平会受到年龄的影响。

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来源期刊

Journal of integrative neuroscience 医学-神经科学

CiteScore

2.80

自引率

5.60%

发文量

173

审稿时长

2 months

期刊介绍： JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.