Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl.

IF 3.3 3区医学 Q3 IMMUNOLOGY Microbial pathogenesis Pub Date : 2024-10-29 DOI:10.1016/j.micpath.2024.107089

Bing Wang , Huihui Tan , Xiuyun Sun , Zizi Lin , Xiayu Chen , Hongguang Han , Mingfang Wang , Zijie Wang , Xiangxiu Chen , Yinyue Deng , Shihao Song

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Abstract

Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases caused by C. albicans. We screened moscatin, and assessed the inhibitory effectiveness against C. albicans SC5314 on hyphae production and biofilm formation. It was revealed that moscatin exhibited significant effects on morphological transition and biofilm formation in C. albicans SC5314. It also lowered the pathogenicity of C. albicans SC5314 in a concentration-dependent way in both A549 cells and mice fungal infection models, but had no cytotoxicity to A549 cells. In addition, moscatin attenuated the virulence of clinical fluconazole-resistant C. albicans and exhibited synergistic activity with fluconazole. It could also restore the composition and richness of the intestinal microbiota in mice infected by C. albicans. These findings indicate that these moscatin has great potential to be developed as a new therapeutic drug against C. albicans infection.

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金钗石斛中的莫斯卡丁对白色念珠菌毒力的抑制作用

白念珠菌感染对全球健康构成重大威胁。当务之急是在不导致耐药性的前提下开发新的抗真菌药物，使这些潜在药物能够补充或结合现有药物，有效治疗由白念珠菌引起的疾病。我们筛选了moscatin，并评估了其对白僵菌SC53145菌丝产生和生物膜形成的抑制效果。结果表明，moscatin 对白僵菌 SC53145 的形态转变和生物膜形成有显著影响。它还以浓度依赖的方式降低了白僵菌 SC53145 在 A549 细胞和小鼠真菌感染模型中的致病性，但对 A549 细胞没有细胞毒性。此外，moscatin 还能减弱对氟康唑耐药的临床白僵菌的毒力，并与氟康唑具有协同活性。它还能恢复被白僵菌感染的小鼠肠道微生物群的组成和丰富度。这些研究结果表明，moscatin 具有很大的开发潜力，可作为治疗白僵菌感染的新药。

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)