Progress in the study of anti-tumor effects and mechanisms of vitexin.

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY Pharmacological Reports Pub Date : 2025-02-01 Epub Date: 2024-10-31 DOI:10.1007/s43440-024-00664-8
Qiming Yang, Rui Huan, Defeng Meng, Junwei Qi, Lei Xia
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Abstract

Vitexin (apigenin-8-C-beta-D-glucopyranoside) is a natural flavonoid derivative with anti-cancer, antioxidant, anti-inflammatory, antihypertensive, anti-asthma, anti-epilepsy, and other therapeutic effects. It is extracted from pearl millet, hawthorn, pigeon bean, mung bean, and other medicinal plants. Vitexin has received widespread attention because of its significant anti-tumor effect. It induces apoptosis and anti-tumor angiogenesis, inhibits tumor cell migration and invasion, regulates tumor cell autophagy and immunity, and increases patient sensitivity to radiotherapy and chemotherapy. It has a significant anti-tumor effect on breast, prostate, liver, cervical, and colon cancers, gliomas, and other malignant tumors. This review demonstrates the latest research progress on the anti-tumor effects and potential mechanisms of vitexin. It summarizes its anti-tumor mechanism to provide new theoretical support and reference for cancer treatment.

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牡荆素抗肿瘤作用和机制的研究进展。
牡荆素(芹菜素-8-C-beta-D-吡喃葡萄糖苷)是一种天然黄酮类衍生物,具有抗癌、抗氧化、抗炎、降血压、抗哮喘、抗癫痫等治疗作用。它是从珍珠粟、山楂、鸽豆、绿豆和其他药用植物中提取的。牡荆素因其显著的抗肿瘤作用而受到广泛关注。它能诱导肿瘤细胞凋亡和抗肿瘤血管生成,抑制肿瘤细胞迁移和侵袭,调节肿瘤细胞自噬和免疫功能,提高患者对放疗和化疗的敏感性。它对乳腺癌、前列腺癌、肝癌、宫颈癌、结肠癌、胶质瘤和其他恶性肿瘤有明显的抗肿瘤作用。本综述展示了有关牡荆素抗肿瘤作用和潜在机制的最新研究进展。总结了其抗肿瘤机理,为癌症治疗提供新的理论支持和参考。
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来源期刊
Pharmacological Reports
Pharmacological Reports 医学-药学
CiteScore
8.40
自引率
0.00%
发文量
91
审稿时长
6 months
期刊介绍: Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.
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