Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL Phytotherapy Research Pub Date : 2024-10-31 DOI:10.1002/ptr.8340
Ali Jafari, Maryam Abbastabar, Alireza Alaghi, Javad Heshmati, Francesca L Crowe, Mahdi Sepidarkish
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Abstract

The aim of this meta-analysis was to determine the effect of curcumin on a range of health outcomes. PubMed, EMBASE, Scopus, and Web of Science were searched from inception until September 2023. Randomized clinical trials (RCTs) that compared the effect of Curcuma longa L. with placebo were considered eligible. The risk of bias and overall certainty of evidence were assessed using the Newcastle-Ottawa Scale and Grading of Recommendations Assessment, Development, and Evaluation (GRADE), respectively. We meta-analyzed the effect sizes across eligible studies using the random-effects model. In total, 103 RCTs on 42 outcomes were included, incorporating a total population of 7216 participants. Overall, 23 out of 42 (55%) outcomes reported statistically significant effect sizes. The credibility of the evidence was rated as high for fasting blood sugar (FBS), C-reactive protein (CRP), high-density lipoprotein (HDL), and weight. The remaining outcomes presented moderate (waist circumference [WC], hip circumference [HC], body mass index [BMI], insulin, Homeostatic Model Assessment for Insulin Resistance [HOMA-IR], quantitative insulin-sensitivity check index [QUICKI], leptin, gamma-glutamyl transferase [GGT], glutathione [GSH], and superoxide dismutase [SOD]), low (14 outcomes), or very low (14 outcomes) evidence. In conclusion, curcumin supplementation can modify FBS and some glycemic indices, lipid parameters, as well as inflammatory and oxidative parameters. This updated summary of the accumulated evidence may help inform clinicians and future guidelines regarding medical and scientific interest in curcumin. However, due to limitations in the methodological quality of the included studies, well-designed and long-term RCTs with large sample sizes are needed. Trial registration: PROSPERO: CRD42021251969.

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姜黄素对人类健康的影响:对 103 项随机对照试验的全面系统回顾和元分析》(Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials)。
这项荟萃分析旨在确定姜黄素对一系列健康结果的影响。我们检索了从开始到 2023 年 9 月的 PubMed、EMBASE、Scopus 和 Web of Science。比较姜黄素与安慰剂效果的随机临床试验(RCT)被认为符合条件。我们采用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale)和建议评估、发展和评价分级法(GRADE)分别评估了偏倚风险和证据的总体确定性。我们采用随机效应模型对所有符合条件的研究的效应大小进行了元分析。共纳入了 103 项研究,涉及 42 种结果,总计 7216 人参与了研究。总体而言,42 项结果中有 23 项(55%)报告了具有统计学意义的效应大小。空腹血糖(FBS)、C 反应蛋白(CRP)、高密度脂蛋白(HDL)和体重的证据可信度被评为高。其余结果(腰围[WC]、臀围[HC]、体重指数[BMI]、胰岛素、胰岛素抵抗自律模型评估[HOMA-IR]、胰岛素敏感性定量检查指数[QUICKI]、瘦素、γ-谷氨酰转移酶[GGT]、谷胱甘肽[GSH]和超氧化物歧化酶[SOD])的证据可信度为中等、低(14 项结果)或极低(14 项结果)。总之,姜黄素补充剂可改变 FBS 和某些血糖指数、血脂参数以及炎症和氧化参数。对累积证据的最新总结有助于为临床医生提供信息,并为姜黄素的医学和科学意义提供未来指南。然而,由于所纳入研究的方法学质量存在局限性,因此还需要设计完善、样本量大的长期 RCT 研究。试验注册:PROCROPERO:CRD42021251969。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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