Exploring Serum Ferritin's Connection to the Acute Phase Response in Zoo-Managed African Rhinoceroses.

IF 1.2 4区 生物学 Q3 VETERINARY SCIENCES Zoo Biology Pub Date : 2024-10-30 DOI:10.1002/zoo.21873
Louisa A Rispoli, Jessye Wojtusik, Terri L Roth
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Abstract

Despite serum ferritin's potential as an iron status indicator, its concentrations vary significantly throughout a black rhinoceros's (Diceros bicornis) life, sometimes irrespective of iron load. We explored acute phase response-related biomarkers, serum amyloid A (SAA) and ceruloplasmin (Cp), to better understand the mechanisms influencing serum ferritin changes in managed black rhinoceroses. The objective was to evaluate the relationships between circulating levels of ferritin, SAA, and Cp in black and white rhinoceroses (Ceratotherium simum). We analyzed banked serum samples collected serially from 11 black (n = 222) and 7 white (n = 134), rhinoceroses (rhinos) and classified samples based on SAA values: clinically healthy (< 1 mg/L), subclinical (1-7 mg/L), or clinically abnormal (> 7 mg/L). In black rhinos, serum ferritin was not different between health status categories (p = 0.5292), nor was it correlated with SAA (p = 0.4164). However, Cp activity was significantly lower in clinically healthy sera (p < 0.0001) and had a moderate positive association with SAA (r = 0.477, p < 0.0001). Among the white rhino samples, only five had SAA values greater than 1 mg/L, limiting the assessment of ferritin and Cp activity in the health context. Minor, yet significant, relationships were observed between serum ferritin and Cp activity, negative in black rhinos (r = -0.206; p = 0.0022) and positive in white rhinos (r = 0.289, p = 0.0008). Cp activity may aid in diagnosing illness in black and white rhinos, based on values observed in sera collected near the time of death. However, acute inflammatory processes do not appear to be one of the primary drivers of the high ferritin concentrations detected in some black rhinos.

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探索血清铁蛋白与动物园管理的非洲犀牛急性期反应的关系。
尽管血清铁蛋白具有作为铁状况指标的潜力,但其浓度在黑犀牛(Diceros bicornis)的一生中变化很大,有时甚至与铁负荷无关。我们探索了与急性期反应相关的生物标志物--血清淀粉样蛋白 A(SAA)和脑磷脂蛋白(Cp),以更好地了解管理黑犀牛血清铁蛋白变化的影响机制。我们的目的是评估黑犀牛和白犀牛体内铁蛋白、SAA 和 Cp 循环水平之间的关系。我们分析了从 11 头黑色犀牛(n = 222)和 7 头白色犀牛(n = 134)身上连续采集的血清样本,并根据 SAA 值对样本进行了分类:临床健康样本(7 mg/L)。在黑犀牛中,不同健康状况类别的血清铁蛋白没有差异(p = 0.5292),也与 SAA 无关(p = 0.4164)。然而,临床健康血清中的 Cp 活性明显较低(p
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来源期刊
Zoo Biology
Zoo Biology 生物-动物学
CiteScore
2.50
自引率
15.40%
发文量
85
审稿时长
6-12 weeks
期刊介绍: Zoo Biology is concerned with reproduction, demographics, genetics, behavior, medicine, husbandry, nutrition, conservation and all empirical aspects of the exhibition and maintenance of wild animals in wildlife parks, zoos, and aquariums. This diverse journal offers a forum for effectively communicating scientific findings, original ideas, and critical thinking related to the role of wildlife collections and their unique contribution to conservation.
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