{"title":"[Cytokines and Myeloproliferative Neoplasms: Current Research Status from Mechanism to Clinic--Review].","authors":"Ye-Chao Tu, Shi-Xuan Wang, Fei Li","doi":"10.19746/j.cnki.issn.1009-2137.2024.05.047","DOIUrl":null,"url":null,"abstract":"<p><p>Myeloproliferative neoplasms (MPN) are a group of malignant myeloid tumors caused by hematopoietic stem cell proliferation. The discovery of gene mutations has elucidated the pathogenesis of MPN and provided molecular diagnostic criteria for MPN. Recent studies have shown that there are cytokine disorders in MPN patients, and the changes in the microenvironment caused by these cytokine disorders may have great significance for the pathophysiology and pathogenesis of MPN, which may lead to corresponding clinical symptoms and different prognosis in patients. In this review, the latest research progress on the role and status of cytokines in MPN will be summarized.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"32 5","pages":"1608-1613"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国实验血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.05.047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Myeloproliferative neoplasms (MPN) are a group of malignant myeloid tumors caused by hematopoietic stem cell proliferation. The discovery of gene mutations has elucidated the pathogenesis of MPN and provided molecular diagnostic criteria for MPN. Recent studies have shown that there are cytokine disorders in MPN patients, and the changes in the microenvironment caused by these cytokine disorders may have great significance for the pathophysiology and pathogenesis of MPN, which may lead to corresponding clinical symptoms and different prognosis in patients. In this review, the latest research progress on the role and status of cytokines in MPN will be summarized.
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