PD-1 inhibitors plus chemotherapy for refractory EBV-positive DLBCL: a retrospective analysis.

IF 2.3 Q2 HEMATOLOGY Blood Research Pub Date : 2024-10-30 DOI:10.1007/s44313-024-00042-6
Youli Li, Yonghe Wu, Sufen Cao, Baohua Yu, Qunling Zhang, Zuguang Xia, Junning Cao, Fangfang Lv, Guang-Liang Chen
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Abstract

Background: Immunochemotherapy has demonstrated a promising efficacy for a variety of B-cell lymphoma but has limited efficacy for Epstein-Barr virus-positive (EBV +) diffuse large B-cell lymphoma (DLBCL) that is refractory or relapsed to conventional chemotherapy regimens. Considering higher programmed death-ligand 1 (PD-L1) expression in the subset of patients with DLBCL with positive EBV, we speculated that PD-1 inhibitors plus chemotherapy may be an alternative regimen in patients with refractory/relapsed EBV + DLBCL.

Methods: This retrospective study included six adult patients diagnosed with refractory EBV + DLBCL resistant to first-line immunochemotherapy regimens (R-CHOP). These patients received PD-1 inhibitors plus chemotherapy as second-line treatment.

Results: The final analysis included six patients (four men and two women (median age, 50 years; range, 39-83 years)). Four patients were diagnosed with Epstein-Barr virus (EBV) + DLBCL, and two had DLBCL associated with chronic inflammation. Over a median follow-up of 20 months (range, 2-31 months), the objective response rate was 83% (5/6) and the complete remission rate was 67% (4/6). No severe immune-related adverse reactions occurred, and only a mild rash was reported, which did not necessitate the discontinuation of therapy.

Conclusion: The combination of PD-1 inhibitors and chemotherapy offers promising results as a second-line treatment for patients with refractory EBV + DLBCL that is resistant to first-line immunochemotherapy regimens. These preliminary findings warrant further investigation in larger clinical trials to validate the efficacy and safety of this therapeutic approach.

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PD-1抑制剂联合化疗治疗难治性EBV阳性DLBCL:一项回顾性分析。
背景:免疫化疗对多种 B 细胞淋巴瘤具有良好的疗效,但对常规化疗方案难治或复发的 Epstein-Barr 病毒阳性(EBV +)弥漫大 B 细胞淋巴瘤(DLBCL)疗效有限。考虑到EBV阳性的DLBCL患者中程序性死亡配体1(PD-L1)表达较高,我们推测PD-1抑制剂加化疗可能是EBV+DLBCL难治/复发患者的另一种治疗方案:这项回顾性研究纳入了六名对一线免疫化疗方案(R-CHOP)耐药的难治性EBV + DLBCL成人患者。这些患者接受了PD-1抑制剂加化疗的二线治疗:最终分析包括六名患者(四名男性和两名女性,中位年龄 50 岁;范围 39-83 岁)。四名患者被诊断为Epstein-Barr病毒(EBV)+ DLBCL,两名患者的DLBCL伴有慢性炎症。中位随访时间为20个月(2-31个月),客观反应率为83%(5/6),完全缓解率为67%(4/6)。未出现严重的免疫相关不良反应,仅有轻微皮疹,但无需停止治疗:结论:PD-1抑制剂与化疗的联合治疗为对一线免疫化疗方案耐药的难治性EBV+DLBCL患者提供了有希望的二线治疗方案。这些初步研究结果值得在更大规模的临床试验中进一步研究,以验证这种治疗方法的有效性和安全性。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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