RETRACTION: Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) Exert Their Anti-proliferative Activity by Interfering With Akt-mTOR Signaling and bax:bcl-2 Ratio Modulation in Cells From Chronic Myeloid Leukemic Patients.

IF 5.7 2区医学 Q1 Medicine Cancer Science Pub Date : 2024-10-30 DOI:10.1111/cas.16390

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引用次数: 0

Abstract

Retraction: C. Di Stefano, G. Marfe, M. M. Trawinska, P. Sinibaldi-Salimei, R. Silvestri, S. Amadori and E. Abruzzese, "Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) Exert Their Anti-proliferative Activity by Interfering With Akt-mTOR Signaling and bax:bcl-2 Ratio Modulation in Cells From Chronic Myeloid Leukemic Patients," Cancer Science 101, no. 4 (2010): 991-1000, https://doi.org/10.1111/j.1349-7006.2010.01490.x. The above article, published online on 07 January 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; the Japanese Cancer Association; and John Wiley & Sons Australia, Ltd. The retraction has been agreed due to several instances of duplications of western blot bands observed in Figures 3, 4, 5 and 8. Furthermore, splicing and deletion of bands was uncovered in Figures 4 and 7 respectively. Finally, western blot bands presented in Figure 4 was also found published earlier in another article. The authors provided partial raw data but the inconsistencies found could not be resolved on this basis. Due to the extent and nature of the duplications, the editors consider the results and conclusions of this study invalid.

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返回：吡咯并[1,2-b][1,2,5]苯并噻二氮卓（PBTDs）通过干扰慢性骨髓性白血病患者细胞中 Akt-mTOR 信号传导和 bax:bcl-2 比率调节发挥抗增殖活性。

撤回：C. Di Stefano、G. Marfe、M. M. Trawinska、P. Sinibaldi-Salimei、R. Silvestri、S. Amadori 和 E. Abruzzese，"吡咯并[1,2-b][1,2,5]苯并噻二氮卓（PBTDs）发挥抗增殖作用"。Abruzzese, "Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) Exert Their Anti-proliferative Activity by Interfering With Akt-mTOR Signaling and bax:bcl-2 Ratio Modulation in Cells from Chronic Myeloid Leukemic Patients," Cancer Science 101, no.4 (2010):991-1000，https://doi.org/10.1111/j.1349-7006.2010.01490.x。上述文章于 2010 年 1 月 7 日在线发表于 Wiley Online Library (wileyonlinelibrary.com)，经杂志主编 Masanori Hatakeyama、日本癌症协会和 John Wiley & Sons Australia, Ltd.协商，该文章已被撤回。同意撤稿的原因是在图 3、图 4、图 5 和图 8 中观察到多处 Western 印迹条带重复。此外，图 4 和图 7 分别发现了条带的拼接和删除。最后，图 4 中显示的 Western 印迹条带也是早先在另一篇文章中发现的。作者提供了部分原始数据，但发现的不一致之处无法据此解决。由于重复的程度和性质，编辑认为这项研究的结果和结论无效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.