A novel Non-rodent animal model of hydrochloric acid-induced acute and chronic lung injury.

IF 5.8 2区医学 Q1 Medicine Respiratory Research Pub Date : 2024-10-29 DOI:10.1186/s12931-024-03022-7

Pavel A Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Christiana Dimitropoulou, John D Catravas

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Abstract

Hydrochloric acid is one of the most prevalent and hazardous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural, and functional aspects of the development of chronic lung injury and pulmonary fibrosis caused by intratracheal instillation of HCl in mice. Although mouse models of human disease have many advantages, rodents are evolutionary far from human and exhibit significant anatomical and physiological differences. Genetic and anatomic similarities between rabbits and humans are significantly higher. Rabbit models of HCl-induced lung injury have been used sparsely to evaluate acute lung injury. In this study, for the first time, we utilized rabbits as a model of HCl-induced pulmonary fibrosis and chronic lung injury. We present molecular, histological, and functional evidence that demonstrate the utility of using this model for studying new pharmaceutics against pulmonary fibrosis.

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盐酸诱发急性和慢性肺损伤的新型非啮齿动物模型

盐酸是最常见的危险化学品之一。工业厂房或运输过程中会发生意外泄漏。接触盐酸会导致严重的健康损害，包括急性和慢性肺部疾病。我们以前曾描述过气管内灌注盐酸导致小鼠慢性肺损伤和肺纤维化的分子、结构和功能方面的发展。虽然人类疾病的小鼠模型有很多优点，但啮齿类动物在进化过程中与人类相差甚远，而且在解剖学和生理学方面也有显著差异。兔子与人类在遗传和解剖方面的相似性要高得多。HCl 诱导的肺损伤兔模型很少用于评估急性肺损伤。在本研究中，我们首次利用兔子作为 HCl 诱导的肺纤维化和慢性肺损伤的模型。我们提出了分子、组织学和功能方面的证据，证明了使用该模型研究抗肺纤维化新药的实用性。

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来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.