Marital dissolution and cognition: The mediating effect of Aβ neuropathology.

IF 4 Q1 CLINICAL NEUROLOGY Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-10-29 eCollection Date: 2024-10-01 DOI:10.1002/dad2.70032

Avinash Chandra, Rifah Anjum, Sheena Waters, Petroula Proitsi, Laura J Smith, Charles R Marshall

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Abstract

Introduction: Widowhood and divorce are extremely stressful life events that are associated with dementia, but the neurobiological underpinnings of this risk remain unknown. Amyloid beta (Aβ) load may explain influences of chronic stress, commonly seen in disruptive marital transitions, on cognitive decline.

Methods: We examined whether Aβ quantified by tracer uptake on positron emission tomography mediates associations between marital dissolution and executive functioning and episodic memory performance using data from 543 cognitively normal (CN) participants from the Alzheimer's Disease Neuroimaging Initiative.

Results: Marriage dissolution was associated with increased Aβ burden (β = 0.56; P = 0.015) and worse memory performance (β = -0.09; P = 0.003). Aβ levels were a significant mediator for the relationship between marriage dissolution and memory (average causal mediation effect = -0.007; P = 0.029).

Discussion: Findings suggest that stressful life events, such as the dissolution of one's marriage, might exert an effect on Alzheimer's disease proteinopathy, which may subsequently influence poor cognition.Highlights: Marital dissolution was associated with increased amyloid beta (Aβ) and memory declines.Aβ burden mediated associations between marital dissolution and memory.Findings were robust to potential non-linear influences of age.Mediation results were not observed when stratifying marital groups by sex.

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婚姻解体与认知：Aβ神经病理学的中介效应。

简介丧偶和离婚是与痴呆症相关的极度紧张的生活事件，但这种风险的神经生物学基础仍然未知。淀粉样蛋白β（Aβ）负荷可以解释长期压力对认知能力下降的影响，而这种影响通常出现在破坏性的婚姻转变中：方法：我们利用阿尔茨海默病神经影像学倡议（Alzheimer's Disease Neuroimaging Initiative）的 543 名认知正常（CN）参与者的数据，研究了通过正电子发射断层扫描示踪剂摄取量化的 Aβ 是否介导婚姻解体与执行功能和外显记忆表现之间的关系：婚姻解体与Aβ负担增加（β = 0.56; P = 0.015）和记忆表现变差（β = -0.09; P = 0.003）有关。Aβ水平是婚姻解体与记忆力之间关系的重要中介（平均因果中介效应=-0.007；P=0.029）：讨论：研究结果表明，婚姻解体等生活压力事件可能会对阿尔茨海默病蛋白病变产生影响，进而影响认知能力：婚姻解体与淀粉样蛋白β（Aβ）增加和记忆力下降有关，Aβ负担在婚姻解体和记忆力之间起中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.