Evaluating Depth of Invasion as a Continuous Prognostic Factor in Oral Squamous Cell Carcinoma

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-10-30 DOI:10.1002/hed.27979

Nofar Edri, Dean Dudkiewicz, Dan Yaniv, Amit Ritter, Yulia Strenov, Aviram Mizrachi, Gideon Bachar, Thomas Shpitzer, Eyal Yosefof

{"title":"Evaluating Depth of Invasion as a Continuous Prognostic Factor in Oral Squamous Cell Carcinoma","authors":"Nofar Edri, Dean Dudkiewicz, Dan Yaniv, Amit Ritter, Yulia Strenov, Aviram Mizrachi, Gideon Bachar, Thomas Shpitzer, Eyal Yosefof","doi":"10.1002/hed.27979","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Depth of invasion (DOI) has a significant clinical impact on the staging system of oral squamous cell carcinoma (OSCC). We aimed to compare the prognostic impact of treating DOI as a continuous variable rather than a categorical one.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective review of 277 OSCC patients surgically treated in a tertiary care center from 2000 to 2020, with a minimum 2-year follow-up. The analyses were performed using Cox and logistic regression.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>DOI as a continuous variable significantly predicted mortality in both univariate (<i>p</i> < 0.001) and multivariate (<i>p</i> < 0.001) analyses. It was also a significant predictor of locoregional recurrence (multivariate <i>p</i> = 0.039) and occult lymph node metastasis (univariate <i>p</i> = 0.005, multivariate <i>p</i> = 0.04). Categorical analysis failed to demonstrate the same significance.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>DOI as a continuous factor rather than a categorical one is significantly associated with mortality, locoregional recurrence, and occult lymph node metastasis. This innovative approach promotes personalized risk stratification and better decision-making.</p>\n </section>\n </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 3","pages":"856-866"},"PeriodicalIF":2.2000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.27979","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hed.27979","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Depth of invasion (DOI) has a significant clinical impact on the staging system of oral squamous cell carcinoma (OSCC). We aimed to compare the prognostic impact of treating DOI as a continuous variable rather than a categorical one.

Methods

A retrospective review of 277 OSCC patients surgically treated in a tertiary care center from 2000 to 2020, with a minimum 2-year follow-up. The analyses were performed using Cox and logistic regression.

Results

DOI as a continuous variable significantly predicted mortality in both univariate (p < 0.001) and multivariate (p < 0.001) analyses. It was also a significant predictor of locoregional recurrence (multivariate p = 0.039) and occult lymph node metastasis (univariate p = 0.005, multivariate p = 0.04). Categorical analysis failed to demonstrate the same significance.

Conclusions

DOI as a continuous factor rather than a categorical one is significantly associated with mortality, locoregional recurrence, and occult lymph node metastasis. This innovative approach promotes personalized risk stratification and better decision-making.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

评估作为口腔鳞状细胞癌持续预后因素的侵袭深度

背景：浸润深度（DOI）对口腔鳞状细胞癌（OSCC）的分期系统有重要的临床影响。我们的目的是比较将 DOI 作为连续变量而非分类变量对预后的影响：方法：对2000年至2020年在一家三级医疗中心接受手术治疗的277例OSCC患者进行回顾性研究，随访至少2年。结果：DOI作为连续变量能显著预测OSCC的发病率：结果：DOI作为一个连续变量，在单变量（p 结论：DOI作为一个连续变量，而不是单变量（p 结论：DOI作为一个连续变量，而不是单变量（pDOI作为连续变量而非分类变量，与死亡率、局部复发和隐匿性淋巴结转移有显著相关性。这种创新方法可促进个性化风险分层和更好的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.