Risk factors for bacteremia in infants with urinary tract infection.

IF 2.3 4区医学 Q2 PEDIATRICS Pediatrics and Neonatology Pub Date : 2024-10-19 DOI:10.1016/j.pedneo.2024.09.004

Hsiang-Chin Chiu, Chih-Chieh Yang, Cai-Sin Yao, Shih-Ju Huang, Nai-Wen Fang

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Abstract

Background: Some infants with urinary tract infection (UTI) may exhibit concurrent bacteremia, potentially leading to septic shock or bacterial meningitis. Identifying risk factors for bacteremia in infants with UTI is crucial for prompt intervention to prevent subsequent adverse outcomes.

Methods: Between 2015 and 2021, a total of 632 infants with UTI aged ≤12 months were enrolled at Kaohsiung Veterans General Hospital (KSVGH), among whom 20 had concurrent bacteremia. We analyzed their differences in outcomes and demographic, clinical, and laboratory characteristics. Independent risk factors for bacteremic UTI were identified using binary logistic regression analysis.

Results: A positive underlying disease (including congenital anomalies of kidney and urinary tract [CAKUT] and prematurity), C-reactive protein (CRP) > 8 mg/dL, lower body weight, and positive urinary nitrite were independent risk factors for infants with UTI and bacteremia.

Conclusions: Physicians should be mindful of the potential for bacteremia to develop in infants with UTI, particularly those with concurrent positive underlying diseases or CRP >8 mg/dL.

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婴儿尿路感染菌血症的风险因素。

背景：一些患有尿路感染（UTI）的婴儿可能会并发菌血症，从而可能导致脓毒性休克或细菌性脑膜炎。确定尿路感染婴儿发生菌血症的风险因素对于及时干预以防止后续不良后果的发生至关重要：方法：2015年至2021年间，高雄荣民总医院共收治了632名年龄小于12个月的UTI婴儿，其中20名同时患有菌血症。我们分析了他们在预后、人口统计学、临床和实验室特征方面的差异。通过二元逻辑回归分析确定了菌血症性UTI的独立风险因素：结果：阳性基础疾病（包括肾脏和泌尿道先天性异常 [CAKUT] 和早产）、C 反应蛋白 (CRP) > 8 mg/dL、体重较轻和尿亚硝酸盐阳性是婴儿患 UTI 和菌血症的独立风险因素：医生应注意尿毒症婴儿，尤其是同时患有阳性基础疾病或 CRP >8 mg/dL 的婴儿发生菌血症的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics and Neonatology PEDIATRICS-

CiteScore

3.10

自引率

0.00%

发文量

170

审稿时长

48 days

期刊介绍： Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.