Functional brain hubs are related to age: A primer study with rs-fMRI

IF 5.3 1区心理学 Q1 PSYCHOLOGY, CLINICAL International Journal of Clinical and Health Psychology Pub Date : 2024-10-01 DOI:10.1016/j.ijchp.2024.100517

María D. Figueroa-Jiménez , Cristina Cañete-Massé , Esteve Gudayol-Ferre , Geisa B. Gallardo-Moreno , Maribel Peró-Cebollero , Joan Guàrdia-Olmos

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Abstract

Background/Objective

Research on the ontogenetic development of brain networks using resting state has shown to be useful for understanding age-associated changes in brain connectivity. This work aimed to analyze the relationship between brain connectivity, age and intelligence.

Methods

A sample of 26 children and adolescents between 6 and 18 years of both sexes underwent a resting-state functional magnetic resonance imaging study. We estimated the values of fractional Amplitude low-frequency fluctuations (fALFF) and the values of Regional homogeneity (ReHo) in a voxelwise analysis to later correlate them with age and intelligence quotient (IQ).

Results

No significant correlations were found with IQ, but it was found that the fALFF values of the left precentral cortex (premotor cortex and supplementary motor area), as well as the ReHo values of the medial frontal gyrus, and the precentral cortex of the left hemisphere, correlate with age. Conclusions: Hubs related to various “task positive” networks closely related to cognitive functioning would present a development more related to age and relatively independent of individual differences in intelligence. These findings suggest that the premotor cortex and supplementary motor cortex could be a cortical hub that develops earlier than previously reported and that it would be more related to age than to intelligence level.

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大脑功能枢纽与年龄有关：利用 rs-fMRI 进行的初步研究

背景/目的利用静息状态对大脑网络的本体发育进行的研究表明，它有助于了解与年龄相关的大脑连通性变化。本研究旨在分析大脑连通性、年龄和智力之间的关系。方法对26名6至18岁的儿童和青少年进行了静息状态功能磁共振成像研究。我们在体素分析中估算了分数振幅低频波动（fALFF）值和区域同质性（ReHo）值，随后将其与年龄和智商（IQ）相关联。结果未发现与智商有明显相关性，但发现左半球前中央皮层（运动前皮层和辅助运动区）的 fALFF 值以及左半球额叶内侧回和前中央皮层的 ReHo 值与年龄相关。结论与认知功能密切相关的各种 "积极任务 "网络枢纽的发展与年龄的关系更为密切，而且与个体智力差异相对独立。这些研究结果表明，前运动皮层和辅助运动皮层可能是一个皮层枢纽，它的发育早于之前的报道，而且与年龄的关系大于与智力水平的关系。

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来源期刊

International Journal of Clinical and Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

10.70

自引率

5.70%

发文量

审稿时长

33 days

期刊介绍： The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.