Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant: A paired experimental animal study

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-10-28 DOI:10.1016/j.jmbbm.2024.106789

Sarah S. Freund , Anna B. Borgognoni , Michael M. Bendtsen , Jørgen Baas , Jeppe S. Byskov , Bahram Ranjkesh , Steen Bærentzen , Jens R. Nyengaard , Thomas Baad-Hansen

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Abstract

Background

Soft-tissue attachment is crucial for the success of megaprosthesis surgery and improvement in current treatment is needed. The aim of this study was to compare the biomechanical and histomorphometric properties of soft-tissue attachment between 3D printed Ti6Al4V implants featuring a 630 μm microporous structure and commercially available Trevira® implants with a 200 μm porous structure in a non-loadbearing ovine model.

Methods

Ten skeletally mature ewes underwent surgical implantation with both implants. After 4-weeks, mechanical pull-out testing assessed the attachment strength, while histomorphometric analysis evaluated fibroblast cell profile density, multinucleated giant cell profile density, microvessel length and volume density.

Results

3D printed Ti6Al4V implants demonstrated a 129% greater attachment strength compared to Trevira® implants (p = 0.003). In the Trevira® group, a 35% increase in fibroblast profile density (p < 0.001) and a 98% increase in multinucleated giant cell profile density (p < 0.001) were observed, with no significant difference in microvessel length density between the groups. However, the Ti6Al4V group exhibited a 50% higher microvessel volume density (p < 0.001) compared to the Trevira® group.

Conclusion

3D printed Ti6Al4V implants with a 630 μm microporous structure demonstrated superior attachment strength, enhanced neovascularization, and reduced foreign body reaction compared to the Trevira® implants. These findings suggest that 3D printed Ti6Al4V implants may enhance soft-tissue attachment in megaprosthesis surgeries.

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三维打印 Ti6Al4V 植入体与 Trevira® 植入体的肌腱附着情况比较：配对实验动物研究

背景软组织附着是巨型假体手术成功的关键，目前的治疗方法需要改进。本研究的目的是在非承重绵羊模型中比较具有 630 μm 微孔结构的 3D 打印 Ti6Al4V 植入体和具有 200 μm 多孔结构的市售 Trevira® 植入体的软组织附着生物力学和组织形态学特性。4 周后，机械拉出测试评估了附着强度，组织形态分析评估了成纤维细胞轮廓密度、多核巨细胞轮廓密度、微血管长度和体积密度。在 Trevira® 组中，成纤维细胞轮廓密度增加了 35%（p = 0.001），多核巨细胞轮廓密度增加了 98%（p = 0.001），两组之间的微血管长度密度没有显著差异。结论与 Trevira® 植入体相比，具有 630 μm 微孔结构的三维打印 Ti6Al4V 植入体表现出更高的附着强度、更强的新生血管生成能力以及更低的异物反应。这些研究结果表明，3D 打印 Ti6Al4V 植入体可增强巨型假体手术中的软组织附着。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.