Irisin in degenerative musculoskeletal diseases: Functions in system and potential in therapy

IF 9.1 2区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological research Pub Date : 2024-10-25 DOI:10.1016/j.phrs.2024.107480
Yu-tong Wang , Sheng-yuan Zheng , Shi-de Jiang , Yan Luo , Yu-xiang Wu , Shinen Naranmandakh , Yu-sheng Li , Shu-guang Liu , Wen-feng Xiao
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Abstract

Degenerative musculoskeletal diseases are a class of diseases related to the gradual structural and functional deterioration of muscles, joints, and bones, including osteoarthritis (OA), osteoporosis (OP), sarcopenia (SP), and intervertebral disc degeneration (IDD). As the proportion of aging people around the world increases, degenerative musculoskeletal diseases not only have a multifaceted impact on patients, but also impose a huge burden on the medical industry in various countries. Therefore, it is crucial to find key regulatory factors and potential therapeutic targets. Recent studies have shown that irisin plays an important role in degenerative musculoskeletal diseases, suggesting that it may become a key molecule in the prevention and treatment of degenerative diseases of the musculoskeletal system. Therefore, this review provides a comprehensive description of the release and basic functions of irisin, and summarizes the role of irisin in OA, OP, SP, and IDD from a cellular and tissue perspective, providing comprehensive basis for clinical application. In addition, we summarized the many roles of irisin as a key information molecule in bone-muscle-adipose crosstalk and a regulatory molecule involved in inflammation, senescence, and cell death, and proposed the interesting possibility of irisin in degenerative musculoskeletal diseases.
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退行性肌肉骨骼疾病中的鸢尾素:系统功能和治疗潜力
肌肉骨骼退行性疾病是指肌肉、关节和骨骼的结构和功能逐渐退化的一类疾病,包括骨关节炎(OA)、骨质疏松症(OP)、肌肉疏松症(SP)和椎间盘退行性变(IDD)。随着全球老龄化人口比例的增加,退行性肌肉骨骼疾病不仅对患者造成了多方面的影响,也给各国的医疗行业带来了巨大的负担。因此,寻找关键调控因子和潜在治疗靶点至关重要。最近的研究表明,鸢尾素在退行性肌肉骨骼疾病中发挥着重要作用,这表明它可能成为预防和治疗肌肉骨骼系统退行性疾病的关键分子。因此,本综述全面阐述了鸢尾素的释放和基本功能,并从细胞和组织的角度总结了鸢尾素在 OA、OP、SP 和 IDD 中的作用,为临床应用提供了全面的依据。此外,我们还总结了鸢尾素作为骨-肌肉-脂肪串联过程中的关键信息分子以及参与炎症、衰老和细胞死亡的调控分子的多种作用,并提出了鸢尾素在退行性肌肉骨骼疾病中的有趣可能性。
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来源期刊
Pharmacological research
Pharmacological research 医学-药学
CiteScore
18.70
自引率
3.20%
发文量
491
审稿时长
8 days
期刊介绍: Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.
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