{"title":"Structural and functional alterations in MRI-negative drug-resistant epilepsy and associated gene expression features","authors":"","doi":"10.1016/j.neuroimage.2024.120908","DOIUrl":null,"url":null,"abstract":"<div><div>Neuroimaging techniques have been widely used in the study of epilepsy. However, structural and functional changes in the MRI-negative drug-resistant epilepsy (DRE) and the genetic mechanisms behind the structural alterations remain poorly understood. Using structural and functional MRI, we analyzed gray matter volume (GMV) and regional homogeneity (ReHo) in DRE, drug-sensitive epilepsy (DSE) and healthy controls. Gene expression data from Allen human brain atlas and GMV/ReHo were evaluated to obtain drug resistance-related and epilepsy-associated gene expression and compared with real transcriptional data in blood. We found structural and functional alterations in the cerebellum of DRE patients, which may be related to the mechanisms of drug resistance in DRE. Our study confirms that changes in brain morphology and regional activity in DRE patients may be associated with abnormal gene expression related to nervous system development. And SP1, as an important transcription factor, plays an important role in the mechanism of drug resistance.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NeuroImage","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1053811924004051","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Neuroimaging techniques have been widely used in the study of epilepsy. However, structural and functional changes in the MRI-negative drug-resistant epilepsy (DRE) and the genetic mechanisms behind the structural alterations remain poorly understood. Using structural and functional MRI, we analyzed gray matter volume (GMV) and regional homogeneity (ReHo) in DRE, drug-sensitive epilepsy (DSE) and healthy controls. Gene expression data from Allen human brain atlas and GMV/ReHo were evaluated to obtain drug resistance-related and epilepsy-associated gene expression and compared with real transcriptional data in blood. We found structural and functional alterations in the cerebellum of DRE patients, which may be related to the mechanisms of drug resistance in DRE. Our study confirms that changes in brain morphology and regional activity in DRE patients may be associated with abnormal gene expression related to nervous system development. And SP1, as an important transcription factor, plays an important role in the mechanism of drug resistance.
神经成像技术已广泛应用于癫痫研究。然而，人们对核磁共振成像阴性的耐药性癫痫（DRE）的结构和功能变化以及结构变化背后的遗传机制仍然知之甚少。我们利用结构性和功能性核磁共振成像分析了耐药性癫痫（DRE）、药物敏感性癫痫（DSE）和健康对照组的灰质体积（GMV）和区域均匀性（ReHo）。我们评估了Allen人脑图谱和GMV/ReHo的基因表达数据，以获得耐药性相关基因和癫痫相关基因的表达，并与血液中的真实转录数据进行了比较。我们发现 DRE 患者小脑的结构和功能发生了改变，这可能与 DRE 的耐药机制有关。我们的研究证实，DRE 患者大脑形态和区域活动的变化可能与神经系统发育相关的基因表达异常有关。而SP1作为一种重要的转录因子，在耐药机制中发挥着重要作用。
期刊介绍：
NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.
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