Associations between uric acid and depressive symptoms, and the mediating role of immunoinflammatory: Findings from rural older adults

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-10-21 DOI:10.1016/j.bbih.2024.100893
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Abstract

Background

In the low-resource rural areas, older adults may experience prolonged and severe depressive symptoms. This study aimed to investigate the relationship between uric acid, depressive symptoms and immunoinflammatory among rural older adults.

Method

This case-control study was conducted in 17 rural villages in Hunan Province, China, between January 2023 and April 2024. This study included 180 participants: (1) Rural Older Adults with Depressive Symptoms group:90 patients with first-time diagnosed with depressive symptoms (Geriatric Depression Scale-15, GDS-15 ≥ 5 scores); (2) Control group: 90 individually matched (age and sex) healthy subjects (GDS-15 < 5 scores) who were aged ≥60 years.

Results

Both males and females, depressive symptoms were associated with higher uric acid levels and C-reactive protein levels (All P < 0.05). Whereas in females, depressive symptoms were also linked to higher procalcitonin (P = 0.005) and serum amyloid A (P = 0.008) levels. In addition, C-reactive protein plays a significant mediating role between uric acid and depressive symptoms in males.

Conclusion

Further investigation is necessary to clarify the underlying mechanisms, examine gender-specific disparities, and assess potential therapeutic interventions targeting uric acid and inflammation levels to mitigate mental disorders risk.
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尿酸与抑郁症状之间的关系,以及免疫炎症的中介作用:农村老年人的研究结果
背景在资源匮乏的农村地区,老年人可能会出现长期和严重的抑郁症状。本研究旨在探讨农村老年人尿酸、抑郁症状和免疫炎症之间的关系。方法本病例对照研究于 2023 年 1 月至 2024 年 4 月在中国湖南省的 17 个农村进行。本研究包括 180 名参与者:(1)农村老年人抑郁症状组:90 名首次诊断为抑郁症状的患者(老年抑郁量表-15,GDS-15 ≥ 5 分);(2)对照组:90 名单独配对(年龄和性别)的患者:结果无论男性还是女性,抑郁症状都与尿酸水平和C反应蛋白水平升高有关(均为P 0.05)。女性抑郁症状还与降钙素原(P = 0.005)和血清淀粉样蛋白 A(P = 0.008)水平升高有关。此外,C 反应蛋白在男性尿酸和抑郁症状之间起着重要的中介作用。结论:有必要开展进一步调查,以阐明潜在的机制,研究性别差异,并评估针对尿酸和炎症水平的潜在治疗干预措施,以降低精神障碍风险。
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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