Recent advances in nanogels for drug delivery and biomedical applications

IF 5.8 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Biomaterials Science Pub Date : 2024-11-01 DOI:10.1039/D4BM00224E

Arti Vashist, Gabriela Perez Alvarez, Vianessa Andion Camargo, Andrea D. Raymond, Adriana Yndart Arias, Nagesh Kolishetti, Atul Vashist, Pandiaraj Manickam, Saurabh Aggarwal and Madhavan Nair

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Abstract

Nanotechnology has shown great promise for researchers to develop efficient nanocarriers for better therapy, imaging, and sustained release of drugs. The existing treatments are accompanied by serious toxicity limitations, leading to severe side effects, multiple drug resistance, and off-target activity. In this regard, nanogels have garnered significant attention for their multi-functional role combining advanced therapeutics with imaging in a single platform. Nanogels can be functionalized to target specific tissues which can improve the efficiency of drug delivery and other challenges associated with the existing nanocarriers. Translation of nanogel technology requires more exploration towards stability and enhanced efficiency. In this review, we present the advances and challenges related to nanogels for cancer therapy, ophthalmology, neurological disorders, tuberculosis, wound healing, and anti-viral applications. A perspective on recent research trends of nanogels for translation to clinics is also discussed.

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纳米凝胶在药物输送和生物医学应用方面的最新进展。

纳米技术为研究人员开发高效的纳米载体以实现更好的治疗、成像和药物持续释放带来了巨大希望。现有的治疗方法存在严重的毒性限制，导致严重的副作用、多重耐药性和脱靶活性。在这方面，纳米凝胶因其多功能性而备受关注，它在单一平台中结合了先进的治疗和成像技术。纳米凝胶可针对特定组织进行功能化，从而提高药物输送的效率，并应对与现有纳米载体相关的其他挑战。纳米凝胶技术的转化需要在稳定性和提高效率方面进行更多探索。在这篇综述中，我们将介绍纳米凝胶在癌症治疗、眼科、神经系统疾病、结核病、伤口愈合和抗病毒应用方面的进展和挑战。此外，还讨论了纳米凝胶应用于临床的最新研究趋势。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.