A preliminary study of primary retroperitoneal sarcoma at a tertiary University Hospital in Bangkok, Thailand: a retrospective observational study.

IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Asian Biomedicine Pub Date : 2024-10-31 eCollection Date: 2024-10-01 DOI:10.2478/abm-2024-0031
Suvit Sriussadaporn, Sukanya Sriussadaporn, Rattaplee Pak-Art, Kritaya Kritayakirana, Supparerk Prichayudh, Pasurachate Samorn, Natawat Narueponjirakul, Punthita Aimsupanimitr, Apinan Uthaipaisanwong
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引用次数: 0

Abstract

Background: Retroperitoneal sarcoma (RPS) is rare and difficult to treat with a high recurrent rate. Very little data regarding primary RPS exists in Thailand.

Objectives: To study the outcome of treatment of primary RPS at a tertiary University Hospital in Bangkok, Thailand.

Methods: All patients who had RPS undergoing the first surgical resection at King Chulalongkorn Memorial Hospital from June 2003 to December 2019 were retrospectively enrolled in the study. Perioperative management, results of treatment, postoperative complications, and outcome were analyzed.

Results: Thirty-eight patients entered the study. Large abdominal mass was the most common presentation (90%). Liposarcoma was the most common histology (58%). Twenty patients (53%) had preoperative core needle biopsy and 21 (55%) underwent preoperative radiotherapy (RT). The tumor size ranged from 3 cm to 48 cm (median 22 cm). Five patients (13%) had total mass removal only while 33 (87%) had complete gross resection with ≥1 visceral organ resection. Surgical margins classified as R0, R1, and R2 were 61%, 34%, and 5%, respectively. Five patients (16%) had postoperative complications. There was no 30-day postoperative mortality. The local recurrence rate was 34%. Survival analysis revealed a 5-year overall survival rate of 37% and 5-year disease-free survival rate of 29%. The 5-year and 10-year recurrent rates were 71% and 95%, respectively. Multivariate analysis showed that preoperative radiation was the only factor reducing recurrence (19% vs. 53%, OR: 0.21, P = 0.011).

Conclusion: The preliminary study of outcome of the treatment of primary RPS at our institution showed a fair prognosis of this rare malignancy despite our aggressive surgical approaches. Preoperative radiation may help reduce recurrence in selected primary RPS patients.

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泰国曼谷一家三级甲等大学医院对原发性腹膜后肉瘤的初步研究:一项回顾性观察研究。
背景:腹膜后肉瘤(RPS腹膜后肉瘤(RPS)非常罕见,治疗难度大,复发率高。泰国有关原发性腹膜后肉瘤的数据很少:研究泰国曼谷一家三级大学医院治疗原发性 RPS 的结果:方法:回顾性纳入2003年6月至2019年12月在朱拉隆功国王纪念医院接受首次手术切除的所有RPS患者。对围手术期管理、治疗结果、术后并发症和预后进行了分析:38名患者参与了研究。腹部大肿块是最常见的表现(90%)。脂肪肉瘤是最常见的组织学类型(58%)。20名患者(53%)在术前进行了核心针活检,21名患者(55%)在术前接受了放射治疗(RT)。肿瘤大小从3厘米到48厘米不等(中位数为22厘米)。5名患者(13%)只进行了全部肿块切除,33名患者(87%)进行了完全的大体切除,并切除了≥1个内脏器官。手术切缘分为R0、R1和R2的比例分别为61%、34%和5%。五名患者(16%)出现术后并发症。术后30天无死亡病例。局部复发率为34%。生存分析显示,5年总生存率为37%,5年无病生存率为29%。5年和10年复发率分别为71%和95%。多变量分析显示,术前放疗是降低复发率的唯一因素(19% 对 53%,OR:0.21,P = 0.011):我院对原发性RPS治疗效果的初步研究表明,尽管我们采取了积极的手术方法,但这种罕见恶性肿瘤的预后尚可。术前放疗可能有助于减少部分原发性RPS患者的复发。
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来源期刊
Asian Biomedicine
Asian Biomedicine 医学-医学:研究与实验
CiteScore
1.20
自引率
0.00%
发文量
24
审稿时长
6-12 weeks
期刊介绍: Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.
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