Classification of Infiltrative Heart Diseases MORAL-STAGE System.

IF 2.3 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Clinical Medicine Insights. Cardiology Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI:10.1177/11795468241249075
Elena V Reznik, Thanh Luan Nguyen, Alla N Semyachkina, Maria A Shkolnikova
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Abstract

Infiltrative heart disease (InHD) is a group of diseases characterized by the deposition of abnormal substances in the heart tissue, causing diastolic, less often systolic, dysfunction of the ventricle(s). Their classification still does not exist. In 2013, the MOGE(S) classification of cardiomyopathies was published, taking into account, along with the morphological and functional characteristics of the heart, damage to other organs, the presence of genetic mutations, acquired causes (e.g., myocardial inflammation, autoimmune diseases, storage diseases, amyloidosis), etc. By analogy with it we offer the MORAL-STAGE classification for InHD. It includes ten features: morphofunctional characteristics (M), organ damage (O), risk of cardiac death (R), age of clinical presentation, age of disease-specific therapy initiation (A), localization of the infiltrative process (inside or outside the cell, L), information about the functional class heart failure and stage of infiltrative heart disease (S), treatment (T), abnormal rhythm or conduction (A), genetic or familial nature of inheritance (G), etiology of the process (E). This article summarizes the cornerstones of the MORAL-STAGE classification and its clinical relevance. In addition, new issues are discussed that can be considered in future versions of the MORAL-STAGE classification.

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浸润性心脏病的道德阶段系统分类。
浸润性心脏病(InHD)是一组疾病,其特点是异常物质沉积在心脏组织中,导致心室舒张功能障碍,收缩功能障碍则较少见。目前还没有对其进行分类。2013 年,发布了心肌病的 MOGE(S)分类法,除考虑心脏的形态和功能特征外,还考虑了对其他器官的损害、基因突变的存在、后天原因(如心肌炎症、自身免疫性疾病、储存性疾病、淀粉样变性)等。以此类推,我们提出了针对 InHD 的 "道德阶段 "分类法。它包括十个特征:形态功能特征 (M)、器官损伤 (O)、心脏死亡风险 (R)、临床表现年龄、开始接受特定疾病治疗的年龄 (A)、浸润过程的定位(细胞内或细胞外,L)、心力衰竭功能分级和浸润性心脏病分期信息 (S)、治疗 (T)、异常心律或传导 (A)、遗传或家族遗传 (G)、过程的病因 (E)。本文总结了 MORAL-STAGE 分类的基础及其临床意义。此外,文章还讨论了在未来版本的 MORAL-STAGE 分类中可以考虑的新问题。
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来源期刊
Clinical Medicine Insights. Cardiology
Clinical Medicine Insights. Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.20
自引率
3.30%
发文量
16
审稿时长
8 weeks
期刊最新文献
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