Force-sensing protein expression in response to cardiovascular mechanotransduction.

IF 9.7 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL EBioMedicine Pub Date : 2024-10-30 DOI:10.1016/j.ebiom.2024.105412
Yongtao Wang, Emeli Chatterjee, Guoping Li, Jiahong Xu, Junjie Xiao
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Abstract

Force-sensing biophysical cues in microenvironment, including extracellular matrix performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics, have a significant influence in regulating vascular morphogenesis and cardiac remodeling by mechanotransduction. Once cells perceive these extracellular mechanical stimuli, Piezo activation promotes calcium influx by forming integrin-adhesion-coupling receptors. This induces robust contractility of cytoskeleton structures to further transmit biomechanical alternations into nuclei by regulating Hippo-Yes associated protein (YAP) signaling pathway between cytoplasmic and nuclear translocation. Although biomechanical stimuli are widely studied in cardiovascular diseases, the expression of force-sensing proteins in response to cardiovascular mechanotransduction has not been systematically concluded. Therefore, this review will summarize the force-sensing Piezo, cytoskeleton and YAP proteins to mediate extracellular mechanics, and also give the prominent emphasis on intrinsic connection of these mechanical proteins and cardiovascular mechanotransduction. Extensive insights into cardiovascular mechanics may provide some new strategies for cardiovascular clinical therapy.

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力传感蛋白在心血管机械传导中的表达。
微环境中的力感应生物物理线索,包括细胞外基质的表现、拉伸介导的力学、剪切应力和流动诱导的血流动力学,在通过机械传导调节血管形态发生和心脏重塑方面具有重要影响。一旦细胞感知到这些细胞外机械刺激,Piezo 激活就会通过形成整合素-粘附偶联受体促进钙离子流入。这将诱导细胞骨架结构的强力收缩,通过调节希波-耶斯相关蛋白(YAP)在细胞质和细胞核之间的信号转导途径,进一步将生物力学交替传递到细胞核中。尽管生物力学刺激在心血管疾病中被广泛研究,但力传感蛋白在心血管机械传导中的表达尚未得到系统总结。因此,本综述将总结介导细胞外力学的力传感 Piezo 蛋白、细胞骨架蛋白和 YAP 蛋白,并突出强调这些力学蛋白与心血管机械传导的内在联系。对心血管力学的广泛了解可为心血管临床治疗提供一些新策略。
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来源期刊
EBioMedicine
EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍: eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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