Nada Chaoul, Eleonora Lauricella, Andrea Giglio, Gabriella D'Angelo, Carlo Ganini, Mauro Cives, Camillo Porta
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引用次数: 0
Abstract
Introduction: Systemic treatment options for renal cell carcinoma (RCC) have expanded considerably in recent years, and both tyrosine kinase inhibitors and immune checkpoint inhibitors, alone or in combination, have entered the clinical arena. Adoptive cell immunotherapies have recently revolutionized the treatment of cancer and hold the promise to further advance the treatment of RCC.
Areas covered: In this review, we summarize the latest preclinical and clinical development in the field of adoptive cell immunotherapy for the treatment of RCC, focusing on lymphokine-activated killer (LAK) cells, cytokine-induced killer (CIK) cells, tumor-infiltrating T cells (TILs), TCR-engineered T cells, chimeric antigen receptor (CAR) T cells, and dendritic cell vaccination strategies. Perspectives on emerging cellular products including CAR NK cells, CAR macrophages, as well as γδ T cells are also included.
Expert opinion: So far, areas of greater therapeutic success of adoptive cell therapies include the adjuvant administration of CIK cells and the transfer of anti-CD70 CAR T cells in patients with metastatic RCC. Bench to bedside and back research will be needed to overcome current limitations of adoptive cell therapies in RCC, primarily aiming at improving the safety of immune cell products, optimizing their antitumor activity and generating off-the-shelf products ready for clinical use.
导言：近年来，肾细胞癌（RCC）的全身治疗方案已大大扩展，酪氨酸激酶抑制剂和免疫检查点抑制剂单独或联合应用已进入临床领域。采用细胞免疫疗法最近彻底改变了癌症的治疗，有望进一步推动RCC的治疗：在这篇综述中，我们总结了采用细胞免疫疗法治疗 RCC 领域的最新临床前和临床进展，重点关注淋巴因子激活的杀伤细胞 (LAK)、细胞因子诱导的杀伤细胞 (CIK)、肿瘤浸润 T 细胞 (TIL)、TCR 工程 T 细胞、嵌合抗原受体 (CAR) T 细胞和树突状细胞疫苗接种策略。专家观点还包括对 CAR NK 细胞、CAR 巨噬细胞以及 γδ T 细胞等新兴细胞产品的看法：到目前为止，采用细胞疗法取得较大治疗成功的领域包括 CIK 细胞的辅助给药和转移性 RCC 患者抗 CD70 CAR T 细胞的转移。要克服目前采用细胞疗法治疗RCC的局限性，还需要进行从临床到临床的反向研究，主要目的是提高免疫细胞产品的安全性，优化其抗肿瘤活性，并开发可用于临床的现成产品。
期刊介绍：
Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy.
Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development.
The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease.
The journal welcomes:
Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine
Drug evaluations reviewing the clinical data on a particular biological agent
Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice
Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections:
Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results;
Article Highlights – an executive summary of the author’s most critical points.
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