No impact of anti-inflammatory medication on inflammation-driven recovery following cervical spinal cord injury in rats

IF 4.6 2区 医学 Q1 NEUROSCIENCES Experimental Neurology Pub Date : 2024-10-29 DOI:10.1016/j.expneurol.2024.115039
Jaison Cucarian , Pamela Raposo , Romana Vavrek , Antoinette Nguyen , Brooklynn Nelson , Philippe Monnier , Abel Torres-Espin , Keith Fenrich , Karim Fouad
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Abstract

Following spinal cord injury (SCI), inflammation is associated with the exacerbation of damage to spinal tissue. Consequently, managing inflammation during the acute and subacute phases is a common target in SCI treatment. However, inflammation may also induce potential benefits, including the stimulation of neuroplasticity and repair. This positive role of inflammation in spinal cord healing and functional recovery is not fully understood. To address this knowledge gap, we examined the effects of two common anti-inflammatory medications, Diphenhydramine and Methylprednisolone, on the efficacy of rehabilitative motor training on recovery from subacute cervical SCI in adult rats. Training depends critically on neuroplasticity thus if inflammation is a key regulator, we propose that anti-inflammatory drugs will reduce subsequent recovery. Both drugs were administered orally over one month, alongside task-specific reaching and grasping training.
After treatment, no substantial changes in motor recovery or lesion size between the treated and control groups were observed. Treated animals also did not show any discernible changes in sensory function or anxiety-like behavior. Taken together, our data indicate that the prolonged use of these anti-inflammatory agents at commonly used doses did not profoundly impact recovery following an SCI. Therefore, considering earlier reports of the benefits of pro-inflammatory stimuli on plasticity, further studies in this area are imperative to elucidate the true impact of treating inflammation and its implications for recovery after spinal cord injuries.
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抗炎药物对大鼠颈脊髓损伤后的炎症驱动恢复没有影响。
脊髓损伤(SCI)后,炎症与脊髓组织损伤加重有关。因此,在急性和亚急性阶段控制炎症是脊髓损伤治疗的共同目标。然而,炎症也可能带来潜在的益处,包括刺激神经可塑性和修复。炎症在脊髓愈合和功能恢复中的这种积极作用尚未得到充分认识。为了填补这一知识空白,我们研究了两种常见的抗炎药物苯海拉明和甲泼尼龙对成年大鼠亚急性颈椎 SCI 康复运动训练疗效的影响。训练在很大程度上取决于神经可塑性,因此如果炎症是一个关键的调节因素,我们认为抗炎药物将会降低随后的恢复效果。在进行任务特异性伸手和抓握训练的同时,我们对大鼠口服了两种药物,为期一个月。治疗后,观察到治疗组和对照组在运动恢复或病变大小方面没有实质性变化。接受治疗的动物在感觉功能或焦虑行为方面也没有出现任何明显的变化。综上所述,我们的数据表明,以常用剂量长期使用这些抗炎药物不会对损伤后的恢复产生深远影响。因此,考虑到早先关于促炎刺激对可塑性的益处的报道,必须在这一领域开展进一步研究,以阐明治疗炎症的真正影响及其对脊髓损伤后恢复的意义。
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来源期刊
Experimental Neurology
Experimental Neurology 医学-神经科学
CiteScore
10.10
自引率
3.80%
发文量
258
审稿时长
42 days
期刊介绍: Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.
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