Oxidative Stress and Inflammation in Myocardial Ischemia-Reperfusion Injury: Protective Effects of Plant-Derived Natural Active Compounds.

IF 2.7 4区医学 Q3 TOXICOLOGY Journal of Applied Toxicology Pub Date : 2024-10-31 DOI:10.1002/jat.4719

Jia Chen, Boyu Wang, Tianwei Meng, Chengjia Li, Changxing Liu, Qingnan Liu, Jiameng Wang, Zhiping Liu, Yabin Zhou

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Abstract

Acute myocardial infarction (AMI) remains a leading cause of death among patients with cardiovascular diseases. Percutaneous coronary intervention (PCI) has been the preferred clinical treatment for AMI due to its safety and efficiency. However, research indicates that the rapid restoration of myocardial oxygen supply following PCI can lead to secondary myocardial injury, termed myocardial ischemia-reperfusion injury (MIRI), posing a grave threat to patient survival. Despite ongoing efforts, the mechanisms underlying MIRI are not yet fully elucidated. Among them, oxidative stress and inflammation stand out as critical pathophysiological mechanisms, playing significant roles in MIRI. Natural compounds have shown strong clinical therapeutic potential due to their high efficacy, availability, and low side effects. Many current studies indicate that natural compounds can mitigate MIRI by reducing oxidative stress and inflammatory responses. Therefore, this paper reviews the mechanisms of oxidative stress and inflammation during MIRI and the role of natural compounds in intervening in these processes, aiming to provide a basis and reference for future research and development of drugs for treating MIRI.

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心肌缺血再灌注损伤中的氧化应激和炎症：植物提取的天然活性化合物的保护作用

急性心肌梗死（AMI）仍然是心血管疾病患者的主要死因。经皮冠状动脉介入治疗（PCI）因其安全高效，一直是急性心肌梗死的首选临床治疗方法。然而，研究表明，PCI 术后心肌供氧的快速恢复会导致继发性心肌损伤，即心肌缺血再灌注损伤（MIRI），严重威胁患者的生存。尽管人们一直在努力，但 MIRI 的发病机制仍未完全阐明。其中，氧化应激和炎症是关键的病理生理机制，在 MIRI 中发挥着重要作用。天然化合物因其疗效高、可用性强、副作用小等特点，已显示出强大的临床治疗潜力。目前的许多研究表明，天然化合物可以通过减少氧化应激和炎症反应来缓解 MIRI。因此，本文综述了 MIRI 期间氧化应激和炎症反应的机制以及天然化合物在干预这些过程中的作用，旨在为今后研究和开发治疗 MIRI 的药物提供依据和参考。

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来源期刊

Journal of Applied Toxicology 医学-毒理学

CiteScore

7.00

自引率

6.10%

发文量

145

审稿时长

1 months

期刊介绍： Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.