Black goji berry anthocyanins extend lifespan and enhance the antioxidant defenses in Caenorhabditis elegans via the JNK-1 and DAF-16/FOXO pathways.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2024-11-01 DOI:10.1002/jsfa.13998

Qiuxiong Xu, Bisheng Zheng, Tong Li, Rui Hai Liu

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Abstract

Background: The black goji berry (Lycium ruthenicum Murr.) is known for its abundance of high-quality natural antioxidants, particularly anthocyanins. Black goji berry anthocyanins (BGA) are receiving increasing attention because of their high safety and beneficial biological activities. Studies have shown that oxidative stress is a key factor affecting aging, whereas antioxidants are critical preventive and delaying strategies.

Results: In the present study, we investigated the potential anti-aging effects and mechanism of BGA using the Caenorhabditis elegans model. We found that BGA prolonged the mean lifespan of nematodes and improve their healthspan, including locomotion, pharyngeal pumping rate and stress resistance. Subsequently, we observed a significant decrease in reactive oxygen species and malondialdehyde levels in nematodes after administering BGA. Moreover, BGA enhanced the activities of the antioxidant enzymes superoxide dismutase and catalase, and elevated the glutathione disulfide/glutathione ratio. We confirmed that BGA exerted excellent antioxidative stress activity in nematodes, which may contribute substantially to its anti-aging effects. The health benefits of BGA in C. elegans might be closely related to petunidin-3-O-glucoside, the most abundant anthocyanin in BGA. Further mechanistic investigation revealed that the JNK-1 and DAF-16/FOXO pathways, rather than the calorie restriction pathway, were responsible for the antioxidant stress and life-prolonging effects of BGA in nematodes.

Conclusion: Our research provides a theoretical foundation for studying the anti-aging effect of BGA and a basis for developing black goji berry and its anthocyanins as functional foods with anti-aging and antioxidative stress benefits. © 2024 Society of Chemical Industry.

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黑枸杞花青素通过JNK-1和DAF-16/FOXO途径延长秀丽隐杆线虫的寿命并增强其抗氧化防御能力

背景：黑枸杞（Lycium ruthenicum Murr.）以富含优质天然抗氧化剂，尤其是花青素而闻名。黑枸杞花青素（BGA）因其高度安全性和有益的生物活性而受到越来越多的关注。研究表明，氧化应激是影响衰老的关键因素，而抗氧化剂则是预防和延缓衰老的重要策略：在本研究中，我们利用秀丽隐杆线虫模型研究了 BGA 潜在的抗衰老作用和机制。我们发现 BGA 延长了线虫的平均寿命并改善了它们的健康状况，包括运动能力、咽部抽吸率和抗应激能力。随后，我们观察到线虫体内的活性氧和丙二醛水平在服用 BGA 后显著下降。此外，BGA 还增强了超氧化物歧化酶和过氧化氢酶的活性，并提高了谷胱甘肽二硫化物/谷胱甘肽的比率。我们证实，BGA 在线虫体内具有出色的抗氧化应激活性，这可能是其抗衰老作用的主要原因。BGA 对线虫健康的益处可能与 BGA 中含量最高的花青素 Petunidin-3-O-glucoside 密切相关。进一步的机理研究发现，JNK-1和DAF-16/FOXO途径，而不是卡路里限制途径，是导致线虫体内BGA的抗氧化压力和延长寿命效应的原因：我们的研究为研究 BGA 的抗衰老作用提供了理论基础，也为开发黑枸杞及其花青素作为具有抗衰老和抗氧化应激功效的功能食品奠定了基础。© 2024 化学工业协会。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.