Human keratin matrix in addition to standard of care accelerates healing of venous ulcers: a case series.

IF 1.5 4区医学 Q3 DERMATOLOGY Journal of wound care Pub Date : 2024-11-02 Epub Date: 2024-10-25 DOI:10.12968/jowc.2024.0248

George Koullias, Allison N Ramey-Ward

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Abstract

Objective: Venous leg ulcers (VLUs) are often large and complicated wounds that, despite combinations of advanced wound care techniques and systemic treatment of underlying vascular issues, take many months to heal and have high rates of recurrence. In this study, we investigated the efficacy of a novel wound care solution-human keratin matrix (HKM).

Method: A case series of VLUs were treated with HKM in conjunction with indicated vascular intervention and standard of care (SoC) procedures. For analysis, these wounds were divided into very large (>200 cm²) and smaller (<35 cm²) wounds.

Results: The cohort comprised 16 VLUs (very large=7; smaller=9). Very large VLUs were reduced in size by an average of 71% within 10 weeks, and showed a 50% size reduction within four applications of HKM. Smaller VLUs reduced by 50% in size within the first three weeks of treatment, and 88.9% of these wounds healed completely with an average of 4.5 HKM applications over an average of 6.5 weeks.

Conclusion: The results of this series highlight the potential of HKM, in combination with indicated systemic interventions and SoC, as an effective treatment for hard-to-heal (chronic) VLUs, even in very large wounds.

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人角蛋白基质与标准护理相结合可加速静脉溃疡的愈合：一个病例系列。

目的：腿部静脉溃疡（VLU）通常是大面积的复杂伤口，尽管结合了先进的伤口护理技术和对潜在血管问题的系统治疗，但仍需数月才能愈合，且复发率很高。在这项研究中，我们调查了一种新型伤口护理液--人角蛋白基质（HKM）的疗效：方法：对一系列 VLU 病例进行了 HKM 治疗，同时进行了指定的血管干预和标准护理（SoC）程序。为便于分析，这些伤口被分为超大（>200 平方厘米）和较小（2 平方厘米）伤口：结果：队列中有 16 个 VLU（超大=7；较小=9）。超大 VLU 在 10 周内平均缩小了 71%，在使用四次 HKM 后缩小了 50%。较小的 VLU 在治疗的前三周内缩小了 50%，在平均 6.5 周内使用 4.5 次 HKM 后，88.9% 的伤口完全愈合：本系列研究结果凸显了 HKM 作为一种有效治疗难以愈合（慢性）VLU（即使是非常大的伤口）的方法，与指定的系统干预和 SoC 相结合的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.