Treatment envelope of transcranial histotripsy: challenges and strategies to maximize the treatment location profile.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2024-11-11 DOI:10.1088/1361-6560/ad8d9f
Ning Lu, Ellen M Yeats, Jonathan R Sukovich, Timothy L Hall, Aditya S Pandey, Zhen Xu
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Abstract

A 750 kHz, 360-element ultrasound array has been built for transcranial histotripsy applications. This study aims to evaluate its performance to determine whether this array is adequate for treating a wide range of brain locations through a human skull. Treatment location profiles in 2 excised human skulls were experimentally characterized based on passive cavitation mapping. Full-wave acoustic simulations were performed in 8 human skulls to analyze the ultrasound propagation at shallow targets in skulls with different properties. Results showed that histotripsy successfully generated cavitation from deep to shallow targets within 5 mm from the skull surface in the skull with high SDR and small thickness, whereas in the skull with low SDR and large thickness, the treatment envelope was limited up to 16 mm from the skull surface. Simulation results demonstrated that the treatment envelope was highly dependent on the skull acoustic properties. Pre-focal pressure hotspots were observed in both simulation and experiments when targeting near the skull. For each skull, the acoustic pressure loss increases significantly for shallow targets compared to central targets due to high attenuation, large incident angles, and pre-focal pressure hotspots. Strategies including array design optimization, pose optimization, and amplitude correction, are proposed to broaden the treatment envelope. This study identifies the capabilities and limitations of the 360-element transcranial histotripsy array and suggests strategies for designing the next-generation transcranial histotripsy array to expand the treatment location profile for a future clinical trial.

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经颅组织电切术的治疗包络:最大化治疗位置轮廓的挑战与策略。
我们已经建立了一个 750kHz、360 个元件的超声阵列,用于经颅组织损伤治疗。本研究旨在对其性能进行评估,以确定该阵列是否足以通过人类头骨治疗各种脑部位置。根据被动空化绘图,对 2 个切除的人类头骨中的治疗位置剖面进行了实验表征。在 8 个人类头骨中进行了全波声学模拟,以分析超声波在不同性质的头骨浅目标处的传播情况。结果显示,在高 SDR 和厚度较小的颅骨中,组织碎裂术成功地在距离颅骨表面 5 毫米的范围内产生了从深到浅的空化,而在低 SDR 和厚度较大的颅骨中,治疗包络线被限制在距离颅骨表面 16 毫米的范围内。模拟结果表明,治疗包络高度依赖于头骨的声学特性。在模拟和实验中,当目标靠近头骨时,都观察到了病灶前压力热点。对于每个头骨,由于高衰减、大入射角和前焦点压力热点,浅目标的声压损失比中心目标显著增加。研究提出了包括阵列设计优化、姿势优化和振幅校正在内的策略,以扩大治疗范围。这项研究确定了 360 元经颅组织切动阵列的能力和局限性,并提出了设计下一代经颅组织切动阵列的策略,以扩大未来临床试验的治疗位置轮廓。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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