Animal Models for Mechanical Circulatory Support: A Research Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-29 eCollection Date: 2024-10-01 DOI:10.31083/j.rcm2510351

Buyan-Ochir Orgil, Michelle Chintanaphol, Neely R Alberson, Lea Letourneau, Hugo R Martinez, Jeffrey A Towbin, Enkhsaikhan Purevjav

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Abstract

Heart failure is a clinical syndrome that has become a leading public health problem worldwide. Globally, nearly 64 million individuals are currently affected by heart failure, causing considerable medical, financial, and social challenges. One therapeutic option for patients with advanced heart failure is mechanical circulatory support (MCS) which is widely used for short-term or long-term management. MCS with various ventricular assist devices (VADs) has gained traction in end-stage heart failure treatment as a bridge-to-recovery, -decision, -transplant or -destination therapy. Due to limitations in studying VADs in humans, animal studies have substantially contributed to the development and advancement of MCS devices. Large animals have provided an avenue for developing and testing new VADs and improving surgical strategies for VAD implantation and for evaluating the effects and complications of MCS on hemodynamics and organ function. VAD modeling by utilizing rodents and small animals has been successfully implemented for investigating molecular mechanisms of cardiac unloading after the implantation of MCS. This review will cover the animal research that has resulted in significant advances in the development of MCS devices and the therapeutic care of advanced heart failure.

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机械循环支持的动物模型：研究综述。

心力衰竭是一种临床综合征，已成为全球主要的公共卫生问题。目前，全球有近 6400 万人受到心力衰竭的影响，给医疗、经济和社会带来了巨大挑战。机械循环支持（MCS）是晚期心衰患者的一种治疗选择，被广泛用于短期或长期治疗。使用各种心室辅助装置（VAD）的机械循环支持已在终末期心力衰竭治疗中占据重要地位，可作为恢复、决定、移植或最终治疗的桥梁。由于在人体中研究 VAD 的局限性，动物研究为 MCS 设备的开发和进步做出了重大贡献。大型动物为开发和测试新型 VAD、改进 VAD 植入手术策略以及评估 MCS 对血液动力学和器官功能的影响和并发症提供了途径。利用啮齿类动物和小型动物建立的 VAD 模型已成功用于研究 MCS 植入后心脏卸载的分子机制。本综述将介绍动物研究在 MCS 设备开发和晚期心力衰竭治疗护理方面取得的重大进展。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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