Navigating cold agglutinin-induced hemolytic anemia in developing countries: A case report and literature review.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL SAGE Open Medical Case Reports Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.1177/2050313X241288352
Ayesha Amjad, Syeda Mahrukh Fatima Zaidi, Muhammad Umer Khan, Sajjad Ali Khan
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Abstract

Cold agglutinin-induced hemolytic anemia presents diagnostic and management challenges, particularly in resource-limited settings like Pakistan. A 92-year-old male presented with altered consciousness, fever, weakness, and severe asthenia. Laboratory findings revealed severe anemia, elevated mean corpuscular volume, and deranged renal function tests. The diagnosis was confirmed via a positive Direct Coombs test and elevated cold agglutinin titers. Multidisciplinary management led to symptom resolution, including blood transfusions and immunosuppressive therapy. This case report and literature review emphasize the complexities of diagnosing and managing cold agglutinin-induced hemolytic anemia in Pakistan. By enhancing awareness and understanding of this condition, clinicians can optimize patient outcomes through timely intervention and multidisciplinary care.

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在发展中国家应对冷凝集素诱发的溶血性贫血:病例报告和文献综述。
冷凝集素诱发的溶血性贫血给诊断和治疗带来了挑战,尤其是在巴基斯坦这样资源有限的国家。一名 92 岁的男性患者出现意识改变、发热、虚弱和严重气喘。实验室检查结果显示其患有严重贫血、平均血球容积升高和肾功能检查异常。经直接库姆斯试验阳性和冷凝集素滴度升高确诊。通过多学科治疗,包括输血和免疫抑制治疗,症状得到缓解。本病例报告和文献综述强调了在巴基斯坦诊断和治疗冷凝集素诱发溶血性贫血的复杂性。通过加强对这种疾病的认识和了解,临床医生可以通过及时干预和多学科护理优化患者的治疗效果。
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来源期刊
SAGE Open Medical Case Reports
SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-
CiteScore
0.60
自引率
0.00%
发文量
320
审稿时长
8 weeks
期刊介绍: SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.
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