Coordinated Interactions between the Hippocampus and Retrosplenial Cortex in Spatial Memory.

IF 11 1区 综合性期刊 Q1 Multidisciplinary Research Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.34133/research.0521
Ruiqing Hou, Ziyue Liu, Zichen Jin, Dongxue Huang, Yue Hu, Wenjie Du, Danyi Zhu, Leiting Yang, Yuanfeng Weng, Tifei Yuan, Bin Lu, Yingwei Wang, Yong Ping, Xiao Xiao
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Abstract

While a hippocampal-cortical dialogue is generally thought to mediate memory consolidation, which is crucial for engram function, how it works remains largely unknown. Here, we examined the interplay of neural signals from the retrosplenial cortex (RSC), a neocortical region, and from the hippocampus in memory consolidation by simultaneously recording sharp-wave ripples (SWRs) of dorsal hippocampal CA1 and neural signals of RSC in free-moving mice during the delayed spatial alternation task (DSAT) and subsequent sleep. Hippocampal-RSC coordination during SWRs was identified in nonrapid eye movement (NREM) sleep, reflecting neural reactivation of decision-making in the task, as shown by a peak reactivation strength within SWRs. Using modified generalized linear models (GLMs), we traced information flow through the RSC-CA1-RSC circuit around SWRs during sleep following DSAT. Our findings show that after spatial training, RSC excitatory neurons typically increase CA1 activity prior to hippocampal SWRs, potentially initiating hippocampal memory replay, while inhibitory neurons are activated by hippocampal outputs in post-SWRs. We further identified certain excitatory neurons in the RSC that encoded spatial information related to the DSAT. These neurons, classified as splitters and location-related cells, showed varied responses to hippocampal SWRs. Overall, our study highlights the complex dynamics between the RSC and hippocampal CA1 region during SWRs in NREM sleep, underscoring their critical interplay in spatial memory consolidation.

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空间记忆中海马和后叶皮层之间的协调互动
虽然人们普遍认为海马-皮层对话是记忆巩固的介导因素,而记忆巩固对刻画功能至关重要,但这种对话是如何起作用的在很大程度上仍是未知数。在这里,我们通过在延迟空间交替任务(DSAT)和随后的睡眠过程中同时记录自由移动小鼠背侧海马CA1的锐波波纹(SWR)和RSC的神经信号,研究了来自新皮层区域RSC(retrosplenial cortex)和海马的神经信号在记忆巩固过程中的相互作用。在非快速眼动(NREM)睡眠中确定了SWR期间海马-RSC的协调性,这反映了任务决策中的神经再激活,表现为SWR内的峰值再激活强度。利用改进的广义线性模型(GLMs),我们追踪了在 DSAT 之后的睡眠期间通过 SWRs 周围的 RSC-CA1-RSC 回路的信息流。我们的研究结果表明,在空间训练后,RSC兴奋性神经元通常会在海马SWRs之前增加CA1活动,从而可能启动海马记忆重放,而抑制性神经元则会在SWRs后被海马输出激活。我们进一步确定了 RSC 中某些编码与 DSAT 有关的空间信息的兴奋性神经元。这些神经元被归类为分裂细胞和位置相关细胞,它们对海马 SWR 的反应各不相同。总之,我们的研究强调了在NREM睡眠中SWRs期间RSC和海马CA1区之间复杂的动态变化,突出了它们在空间记忆巩固过程中的重要相互作用。
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来源期刊
Research
Research Multidisciplinary-Multidisciplinary
CiteScore
13.40
自引率
3.60%
发文量
0
审稿时长
14 weeks
期刊介绍: Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
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