An unusual large mass of sclerosing angiomatoid nodular transformation

Abstract

A 23-year-old man was admitted to the hospital after a physical examination revealed a space-occupying lesion in the spleen that had been present for over 2 months. The patient reported no significant symptoms, and laboratory tests showed no abnormalities. Abdominal computed tomography (CT) and abdominal magnetic resonance imaging scans identified a large soft tissue mass in the spleen, measuring 7.1 cm × 5.4 cm × 6.6 cm. A laparoscopic splenectomy was performed. During the procedure, the mass was observed to be dark red, encapsulated, and of medium consistency. Histological examination revealed destruction of the spleen's red and white pulp structure, with notable infiltration of lymphocytes, plasma cells, and histiocytes. Additionally, fibrous tissue hyperplasia and hyalinosis were present, with lobulated nodules forming in certain areas. Immunohistochemical staining results were positive for Vim, CD31, CD4, CD8, CD20, CD3, CD68, SMA, and IgG. The final pathological diagnosis was sclerosing hemangiomatoid nodular transformation of the spleen (sinus lacunar type; Figure 1).

Maoli Xu: Writing—original draft (equal). Zhibing Ruan: Supervision (equal).

The authors declare that they have no conflicts of interest.

Not applicable.

The patient provided written informed consent at the time of entering this study.