Yi Sun, Xin Peng, Yudong Guan, Tong Su, Zezun Xie, Ziying Wu, Yongxuan Long, Huihui Zhu, Jie Shao, Xiaoli Mai, Xuzhi Shi, Tingting Wu, Zhaogang Teng, Bing Zhang, Kun Chen, Xiaoyan Xin
{"title":"K<sub>2</sub>FeO<sub>4</sub>-Enhanced Photodynamic Therapy of Breast Cancer via In Situ Synthesis of Fe<sub>2</sub>O<sub>3</sub> and O<sub>2</sub>.","authors":"Yi Sun, Xin Peng, Yudong Guan, Tong Su, Zezun Xie, Ziying Wu, Yongxuan Long, Huihui Zhu, Jie Shao, Xiaoli Mai, Xuzhi Shi, Tingting Wu, Zhaogang Teng, Bing Zhang, Kun Chen, Xiaoyan Xin","doi":"10.1002/adhm.202402827","DOIUrl":null,"url":null,"abstract":"<p><p>Photodynamic Therapy (PDT) offers a promising minimally invasive treatment for breast cancer, but its efficacy is limited by the hostile tumor microenvironment (TME), including hypoxia and high glutathione (GSH) levels. Although various strategies to improve oxygen concentration or reduce reactive oxygen species (ROS) resistance for enhanced PDT have been explored, they typically require intricate design and complex synthesis of multifunctional nanocarriers. Thus, this study introduces a facile K<sub>2</sub>FeO<sub>4</sub>-induced strategy to enhance PDT efficiency in breast cancer through the tumor in situ synthesis of Fe<sub>2</sub>O<sub>3</sub> and O<sub>2</sub>. Inspired by the successful application of K<sub>2</sub>FeO<sub>4</sub> in ecological remediation and hemostasis, K<sub>2</sub>FeO<sub>4</sub> reacts with GSH, biological system, H<sub>2</sub>O<sub>2</sub>, and water, to generate Fe<sub>2</sub>O<sub>3</sub> and O<sub>2</sub>. Intratumoral injection of K<sub>2</sub>FeO<sub>4</sub> improves the TME, followed by Ce6 administration to enhance PDT through synergistic ferroptosis. This approach boosts PDT efficacy significantly by increasing ROS generation, lipid peroxidation, and inhibiting GSH and GPX4. Proteomic analysis revealed alterations in key pathways, including endocytosis and energy metabolism. This K<sub>2</sub>FeO<sub>4</sub>-PDT strategy creates a positive feedback loop by enhancing oxidative stress, providing an interesting and promising approach to PDT.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/adhm.202402827","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Photodynamic Therapy (PDT) offers a promising minimally invasive treatment for breast cancer, but its efficacy is limited by the hostile tumor microenvironment (TME), including hypoxia and high glutathione (GSH) levels. Although various strategies to improve oxygen concentration or reduce reactive oxygen species (ROS) resistance for enhanced PDT have been explored, they typically require intricate design and complex synthesis of multifunctional nanocarriers. Thus, this study introduces a facile K2FeO4-induced strategy to enhance PDT efficiency in breast cancer through the tumor in situ synthesis of Fe2O3 and O2. Inspired by the successful application of K2FeO4 in ecological remediation and hemostasis, K2FeO4 reacts with GSH, biological system, H2O2, and water, to generate Fe2O3 and O2. Intratumoral injection of K2FeO4 improves the TME, followed by Ce6 administration to enhance PDT through synergistic ferroptosis. This approach boosts PDT efficacy significantly by increasing ROS generation, lipid peroxidation, and inhibiting GSH and GPX4. Proteomic analysis revealed alterations in key pathways, including endocytosis and energy metabolism. This K2FeO4-PDT strategy creates a positive feedback loop by enhancing oxidative stress, providing an interesting and promising approach to PDT.
期刊介绍:
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.