Cannabis Use Among Cancer Patients During Active Treatment: Findings From a Study at an NCI-Designated Cancer Center

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-11-02 DOI:10.1002/cam4.70384

Amrit Baral, Bria-Necole A. Diggs, Ranya Marrakchi El Fellah, Connor McCarley, Frank Penedo, Claudia Martinez, Denise C. Vidot

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Abstract

Objective

This study aims to describe patterns, sources, and reasons for cannabis use among cancer patients during active treatment (+CDTX) compared to no-use during active treatment (−CDTX).

Methods

Data are from 385 surveys collected via REDCap during phase I of an ongoing study among adult cancer patients seen at an NCI-designated comprehensive cancer center within the last 5 years of treatment. A harmonized survey was created with 11 other NCI centers to assess cannabis use patterns, sources, and reasons for use. Sociodemographics and cancer details were also collected via self-report. Descriptive statistics were calculated and stratified by +/−CDTX. Chi-squared tests were conducted to compare proportions between groups.

Results

Among the sample [49.5 years (SD 15.9); 53.0% male; and 41.6% Hispanic/Latino], 41.0% + CDTX and 59.0% −CDTX. A majority (71.8%) of +CDTX initiated use before diagnosis versus 44.1% in −CDTX (p < 0.0001); patients diagnosed with stage 4 cancer had a statistically significant higher prevalence of +CDTX (60.0%; p = 0.003); 53.3% in radiation reported +CDTX compared to 42.8% in chemotherapy, and 36.4% in immunotherapy. Dispensaries and local dealers were the top sources of cannabis in both groups. Among +CDTX, 44.3% consumed cannabis at least once a day DTX, dominant cannabinoids used were CBD (35.2%), Delta-8-THC (18.3%), and CBD + THC ratio (14.1%); 12.7% were unsure what they consumed. Joints were the most common inhalation method (61.5%), and store-bought candy was the most common edible (39.2%). Depression/mood, pain, and enjoyment were the top three reasons for +CDTX compared to enjoyment, depression/mood, and nausea/upset stomach in −CDTX (p = 0.02).

Conclusions

Patterns, sources, and reasons for cannabis use varied between +CDTX and -CDTX. Future studies should examine the impacts of cannabis and specific cannabinoids on cancer treatment, drug interactions, survival outcomes, and quality of life.

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癌症患者在积极治疗期间使用大麻：NCI 指定癌症中心的研究结果。

目的：本研究旨在描述癌症患者在积极治疗期间（+CDTX）与不使用大麻期间（-CDTX）相比使用大麻的模式、来源和原因：本研究旨在描述癌症患者在积极治疗期间（+CDTX）与积极治疗期间不使用大麻（-CDTX）相比的大麻使用模式、来源和原因：数据来自一项正在进行的研究第一阶段通过 REDCap 收集的 385 份调查问卷，调查对象是在 NCI 指定的综合癌症中心就诊的成年癌症患者，他们在过去 5 年的治疗过程中使用过大麻。我们与其他 11 个 NCI 中心共同制作了一份统一调查表，以评估大麻的使用模式、来源和原因。此外，还通过自我报告收集了社会人口统计数据和癌症详情。我们计算了描述性统计数据，并按 +/-CDTX 进行了分层。采用卡方检验比较组间比例：在样本中[49.5 岁（SD 15.9）；53.0% 为男性；41.6% 为西班牙裔/拉丁裔]，41.0% + CDTX，59.0% -CDTX。大多数（71.8%）＋CDTX 在诊断前开始吸毒，而 -CDTX 为 44.1%（P 结论：＋CDTX 在诊断前开始吸毒，而 -CDTX 为 44.1%）：+CDTX和-CDTX使用大麻的模式、来源和原因各不相同。未来的研究应探讨大麻和特定大麻素对癌症治疗、药物相互作用、生存结果和生活质量的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.