Alterations of regional homogeneity and functional connectivity in different hoehn and yahr stages of Parkinson's disease

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-11-01 DOI:10.1016/j.brainresbull.2024.111110

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Abstract

Purpose

Using regional homogeneity (ReHo) and functional connectivity (FC) to assess alterations in brain function and their potential relation to different Hoehn and Yahr (H&Y) stages in Parkinson's disease (PD).

Materials and methods

66 patients with PD and 57 age- and sex-matched healthy control (HC) participants were recruited. All subjects underwent clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI) scanning. We analyzed alterations in regional brain activity using ReHo analyses in all subjects and further explored their relationship to disease severity. Finally, the brain region significantly associated with disease severity was used as a seed point to analyze the FC changes between it and other brain regions in the whole brain.

Results

Compared with HC participants, PD patients showed a significant decrease ReHo in the sensorimotor network (bilateral precentral and postcentral gyrus). The ReHo value of the left precentral gyrus in PD patients decreased with increasing H&Y stage and correlated negatively with Unified Parkinson’s Disease Rating Scale (UPDRS) III scores. Further, FC analysis of the left precentral gyrus as a region of interest showed that functional activity between the left precentral gyrus and sensorimotor network, default network, and visual network was decreased.

Conclusion

The left precentral gyrus plays an important role in the pathophysiological mechanisms of PD patients, and this finding further highlights the potential of the primary motor cortex (M1) as a non-invasive therapeutic target for neuromodulation in PD patients.

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帕金森病不同 Hoehn 和 Yahr 分期的区域同质性和功能连接性的改变

目的：使用区域同质性（ReHo）和功能连通性（FC）评估帕金森病（PD）患者大脑功能的改变及其与不同Hoehn和Yahr（H&Y）分期的潜在关系。材料与方法：招募66名帕金森病患者和57名年龄与性别匹配的健康对照组（HC）参与者。所有受试者均接受了临床评估和静息态功能磁共振成像（rs-fMRI）扫描。我们使用 ReHo 分析方法分析了所有受试者大脑区域活动的变化，并进一步探讨了它们与疾病严重程度的关系。最后，以与疾病严重程度明显相关的脑区为种子点，分析其与全脑其他脑区之间的FC变化：结果：与普通人相比，帕金森病患者感觉运动网络（双侧中央前回和中央后回）的ReHo值明显下降。帕金森病患者左侧前中央回的ReHo值随着H&Y阶段的增加而降低，并与统一帕金森病量表（UPDRS）III评分呈负相关。此外，将左侧中央前回作为感兴趣区进行的FC分析表明，左侧中央前回与感觉运动网络、缺省网络和视觉网络之间的功能活动减少：结论：左侧中央前回在帕金森病患者的病理生理机制中扮演着重要角色，这一发现进一步凸显了初级运动皮层（M1）作为帕金森病患者神经调控非侵入性治疗靶点的潜力。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.