Does a transmembrane sodium gradient control membrane potential in mammalian mitochondria?

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2024-10-23 DOI:10.1016/j.ceca.2024.102962
David G. Nicholls
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引用次数: 0

Abstract

In a recent publication, Hernansanz-Agusti̒n et al. propose that a sodium gradient across the inner mitochondrial membrane, generated by a Na+/H+ activity integral to Complex I can account for half of the mitochondrial membrane potential. This conflicts with conventional electrophysiological and chemiosmotic understanding.
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跨膜钠梯度是否能控制哺乳动物线粒体的膜电位?
在最近发表的一篇文章中,Hernansanz-Agusti̒n 等人提出,线粒体内膜上的钠梯度是由与复合体 I 不可分割的 Na+/H+ 活性产生的,可以占线粒体膜电位的一半。这与传统的电生理学和化学渗透理解相冲突。
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
期刊最新文献
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024) Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary Calcium signals as regulators of ferroptosis in cancer GPCR signalling: Yet another variant route in a highly complex road map Does a transmembrane sodium gradient control membrane potential in mammalian mitochondria?
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