Promising biomarker panel to monitor therapeutic efficacy of neoadjuvant chemotherapy in pancreatic cancer patients.

IF 4.4 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL European Journal of Clinical Investigation Pub Date : 2024-11-02 DOI:10.1111/eci.14341
Josef E Gillson, Sooin Byeon, Angela Chou, Sarah Maloney, Nick Pavlakis, Stephen J Clarke, David L Chan, Connie I Diakos, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal, Sumit Sahni
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Abstract

Background: Neoadjuvant chemotherapy (NAC) can provide improved survival outcomes in pancreatic ductal adenocarcinoma (PDAC) patients who respond to treatment, but currently available biomarkers cannot reliably predict NAC response. This study aimed to determine the potential of a previously identified diagnostic and prognostic biomarker panel (i.e. Ca-125, S100A2, S100A4, Mesothelin and Ca19-9) for the monitoring of NAC-response in PDAC patients.

Methods: This single-centre, retrospective study, utilised serum from NAC treated PDAC patients to determine the levels of biomarkers by Enzyme-Linked Immunosorbent Assay (ELISA). The percentage of the tumour bed occupied by viable carcinoma (PVC) was used to divide patients into good (PVC < 50%) and poor (PVC ≥ 50%) NAC-responders. Statistical analysis was performed to measure the ability of individual biomarkers and a biomarker panel in NAC treatment response and patient survival.

Results: Serum specimens from a total of 108 PDAC patients were assessed. Ca-125, Ca19-9 and S100A2 showed a significant positive correlation with PVC. Ca-125 demonstrated a superior ability to monitor NAC treatment response (Area under receiver operating curve (AUC): .6954) compared to the more widely used clinical biomarker, Ca19-9 (AUC: .6291). A panel of Ca-125 and Ca19-9 showed good ability to monitor NAC response in PDAC patients (AUC: .7349). Patients with high levels of both Ca-125 and Ca19-9 were shown to have the poorest overall survival (median overall survival: 17 vs. 30 months).

Conclusion: A serum biomarker panel of Ca-125 and Ca19-9 could be used for effective clinical management of PDAC patients undergoing NAC treatment.

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用于监测胰腺癌患者新辅助化疗疗效的生物标记物面板前景看好。
背景:新辅助化疗(NAC)可改善对治疗有反应的胰腺导管腺癌(PDAC)患者的生存预后,但目前可用的生物标志物不能可靠地预测NAC反应。本研究旨在确定先前确定的诊断和预后生物标记物面板(即 Ca-125、S100A2、S100A4、间皮素和 Ca19-9)在监测 PDAC 患者 NAC 反应方面的潜力:这项单中心回顾性研究利用 NAC 治疗 PDAC 患者的血清,通过酶联免疫吸附试验(ELISA)确定生物标志物的水平。根据存活癌(PVC)占肿瘤床的百分比,将患者分为良好(PVC 结果)和不良(PVC 结果):共评估了 108 名 PDAC 患者的血清标本。Ca-125、Ca19-9 和 S100A2 与 PVC 呈显著正相关。与更广泛应用的临床生物标记物 Ca19-9(AUC:0.6291)相比,Ca-125 监测 NAC 治疗反应的能力更强(接收器工作曲线下面积(AUC):0.6954)。Ca-125和Ca19-9的组合显示出监测PDAC患者NAC反应的良好能力(AUC:.7349)。Ca-125和Ca19-9水平均较高的患者总生存期最短(中位总生存期:17个月对30个月):结论:Ca-125和Ca19-9血清生物标记物面板可用于对接受NAC治疗的PDAC患者进行有效的临床管理。
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来源期刊
CiteScore
9.50
自引率
3.60%
发文量
192
审稿时长
1 months
期刊介绍: EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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