Serum proteome reveals distinctive molecular features of H7N9- and SARS-CoV-2-infected patients.

IF 7.5 1区生物学 Q1 CELL BIOLOGY Cell reports Pub Date : 2024-11-01 DOI:10.1016/j.celrep.2024.114900

Yunzhi Wang, Zhigang Song, Peng Ran, Hang Xiang, Ziyan Xu, Ning Xu, Mengjie Deng, Lingli Zhu, Yanan Yin, Jinwen Feng, Chen Ding, Wenjun Yang

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Abstract

The coronavirus disease 2019 (COVID-19) pandemic has reminded us of human infections with the H7N9 virus and has raised questions related to the clinical and molecular pathophysiological diversity between the two diseases. Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and healthy controls. Compared to SARS-CoV-2, H7N9-virus infection caused elevated neutrophil concentrations, T cell exhaustion, and increased cytokine/interleukin secretion. Cell-type deconvolution and temporal analysis revealed that T cells and neutrophils could regulate the core immunological trajectory and influence the prognosis of patients with severe H7N9-virus infection. Elevated tissue-enhanced proteins combined with alterations of clinical biochemical indexes suggested that H7N9 infection induced more severe inflammatory organ injury and dysfunction in the liver and intestine. Further mechanical analysis revealed that the high concentration of neutrophils might impact the intestinal enterocyte cells through cytokine-receptor interaction, leading to intestinal damage in patients with H7N9-virus infection.

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血清蛋白质组揭示了 H7N9 和 SARS-CoV-2 感染者的独特分子特征。

2019年冠状病毒病（COVID-19）大流行让我们想起了人类感染的H7N9病毒，并提出了这两种疾病在临床和分子病理生理学方面的多样性问题。在此，我们对 H7N9 病毒或 SARS-CoV-2 病毒感染者和健康对照者的血清样本进行了蛋白质组学研究。与 SARS-CoV-2 相比，H7N9 病毒感染会导致中性粒细胞浓度升高、T 细胞衰竭以及细胞因子/白细胞介素分泌增加。细胞类型解旋和时间分析表明，T 细胞和中性粒细胞可调节核心免疫轨迹，并影响严重 H7N9 病毒感染患者的预后。组织增强蛋白的升高与临床生化指标的改变相结合，表明 H7N9 感染诱发了肝脏和肠道更严重的炎症器官损伤和功能障碍。进一步的机械分析表明，高浓度的中性粒细胞可能通过细胞因子-受体相互作用影响肠道肠细胞，导致 H7N9 病毒感染患者的肠道损伤。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.