Polymeric artificial heart valves derived from modified diol-based polycarbonate polyurethanes

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL Acta Biomaterialia Pub Date : 2024-12-01 DOI:10.1016/j.actbio.2024.10.045
Yage Hu, Yao Xiong, Yuan Wei, Jingze Liu, Tiantian Zheng, Cheng Zheng, Gaocan Li, Rifang Luo, Li Yang, Fanjun Zhang, Yunbing Wang
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Abstract

A series of polycarbonate silicone polyurethanes (SiPCUs) have been synthesized to develop elastomers with the mechanical properties, biostability, and biocompatibility required for artificial heart valve manufacturing. In these SiPCUs, the polar functional group 4,4′-dicyclohexylmethane diisocyanate (HMDI) was incorporated into the soft segment 1,6-poly (hexamethylene carbonate) diol (PCDL) to form the modified macromolecular diol, PCDL-HMDI-PCDL. The hard segment consisted of HMDI and the chain extenders 1,4-butanediol and 1,3-bis(4-hydroxybutyl)-1,1,3,3-tetramethyl disiloxane (BHTD). The synthesized PHC-PCUB improves the excessive microphase separation caused by the introduction of PDMS. This material possesses good physicochemical properties, long-term oxidative degradation stability, and comparatively low mechanical performance loss after degradation. Compared to the commercially available bioprosthetic heart valve (BHV) material Glut-PP, PHC-PCUB demonstrated enhanced biocompatibility, good thromboresistant properties, less calcification, and higher endothelial cell adhesion. Furthermore, valve prototypes fabricated with PHC-PCUB showed improved hemodynamic performance under various simulated conditions, highlighting the potential of PHC-PCUB as an advanced material for valve leaflets.

Statement of significance

Artificial heart valves are crucial for treating valve diseases, and polyurethane-based valves present a promising alternative due to their durability, strong biocompatibility, and customizable properties. This study improves the biostability and post-degradation mechanical properties of siloxane polyurethanes by reducing the content of polydimethylsiloxane (PDMS) and adding modified diol (PCDL-HMDI-PCDL). By integrating hexamethylene diisocyanate (HMDI) and chain extenders, we developed polycarbonate siloxane polyurethanes (SiPCUs) that improve phase mixing, mechanical strength, and oxidative stability. These SiPCUs also exhibit good thromboresistance and calcification resistance, low cytotoxicity, and promote cell adhesion, positioning them as highly promising materials for heart valve leaflets, effectively addressing the limitations of current mechanical and bioprosthetic valves.

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由改性二元醇基聚碳酸酯聚氨酯制成的聚合物人工心脏瓣膜。
为了开发出具有人工心脏瓣膜制造所需的机械性能、生物稳定性和生物相容性的弹性体,人们合成了一系列聚碳酸酯硅氧烷聚氨酯(SiPCUs)。在这些 SiPCU 中,极性官能团 4,4'-二环己基甲烷二异氰酸酯(HMDI)与软段 1,6-聚(碳酸六亚甲基酯)二元醇(PCDL)结合,形成改性大分子二元醇 PCDL-HMDI-PCDL。硬段由 HMDI 和扩链剂 1,4-丁二醇和 1,3-双(4-羟基丁基)-1,1,3,3-四甲基二硅氧烷(BHTD)组成。合成的 PHC-PCUB 可改善因引入 PDMS 而导致的过度微相分离。这种材料具有良好的物理化学特性、长期氧化降解稳定性以及降解后相对较低的机械性能损失。与市场上销售的生物人工心脏瓣膜(BHV)材料 Glut-PP 相比,PHC-PCUB 具有更强的生物相容性、良好的抗血栓性能、更少的钙化和更高的内皮细胞粘附性。此外,用 PHC-PCUB 制作的瓣膜原型在各种模拟条件下显示出更好的血流动力学性能,凸显了 PHC-PCUB 作为先进瓣叶材料的潜力。意义说明:人工心脏瓣膜对治疗瓣膜疾病至关重要,而聚氨酯瓣膜因其耐用性、较强的生物相容性和可定制的特性,成为一种很有前景的替代材料。这项研究通过减少聚二甲基硅氧烷(PDMS)的含量并添加改性二元醇(PCDL-HMDI-PCDL),提高了硅氧烷聚氨酯的生物稳定性和降解后机械性能。通过整合六亚甲基二异氰酸酯(HMDI)和扩链剂,我们开发出了聚碳酸酯硅氧烷聚氨酯(SiPCUs),可改善相混合、机械强度和氧化稳定性。这些 SiPCU 还具有良好的抗血栓形成和抗钙化性能、低细胞毒性和促进细胞粘附性,使其成为极具潜力的心脏瓣膜瓣叶材料,有效解决了目前机械瓣膜和生物人工瓣膜的局限性。
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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