Perspective on the role of pharmacogenetic testing in mental health care in Slovakia.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_106
Michaela Krivosova, Peter Hutka, Sara Kusnierova, Zuzana Macekova, Laura Maggioni, Matteo Marcatili, Massimo Clerici, Juraj Mokry
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Abstract

Background: The pathophysiology of mental illnesses is not fully understood, leading to insufficient remission, frequent adverse drug reactions, and treatment resistance. Pharmacogenetic (PGx) testing, a personalized approach recently adopted also in psychiatry, can guide effective drug therapy and minimize side effects. The objective of this study was to determine the perspective of Slovak clinicians regarding the integration of PGx testing in psychiatric clinical practice.

Methods: Questionnaires covering various aspects such as prior experience with PGx testing, self-perceived competence, perceived utility, potential risks and challenges were distributed directly to attendees at two psychiatric conferences held in Slovakia in 2023 and their responses were statistically analysed.

Results: Out of 54 respondents, only 7.4% had previous experience with PGx in clinical practice. The most clinicians felt that they should possess the skills to apply PGx testing in psychiatric clinical practice and were enthusiastic about increasing their expertise. They found PGx useful in medication selection, adverse effect management, and treatment-resistant depression. The primary concerns centered around the lack of well-defined guidelines and the financial considerations linked to the testing.

Conclusions: Considering the participants' interest in PGx and its integration into clinical practice, educational programmes based on recommendations, guidelines, and convincing evidence could be organized (Tab. 4, Ref. 30). Text in PDF www.elis.sk Keywords: pharmacogenetics, pharmacogenomics, psychiatry, personalized treatment, Slovakia, perspective.

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透视药物基因检测在斯洛伐克精神卫生保健中的作用。
背景:精神疾病的病理生理学尚不完全清楚,导致缓解不足、药物不良反应频发和耐药性。药物基因学(PGx)检测是最近在精神病学中也采用的一种个性化方法,它可以指导有效的药物治疗并最大限度地减少副作用。本研究旨在了解斯洛伐克临床医生对将 PGx 检测纳入精神病临床实践的看法:方法:在 2023 年于斯洛伐克举行的两次精神病学会议上,向与会者直接发放了调查问卷,内容涉及 PGx 检验的先前经验、自我认知能力、认知效用、潜在风险和挑战等各个方面,并对他们的回答进行了统计分析:结果:在 54 位受访者中,只有 7.4% 的人以前在临床实践中使用过 PGx。大多数临床医生认为,他们应该掌握在精神科临床实践中应用 PGx 检验的技能,并热衷于提高自己的专业知识。他们认为 PGx 在药物选择、不良反应管理和治疗耐药抑郁症方面非常有用。他们的主要顾虑是缺乏明确的指导原则以及与测试相关的财务考虑:考虑到参与者对 PGx 及其与临床实践相结合的兴趣,可以组织基于建议、指南和令人信服的证据的教育计划(表 4,参考文献 30)。Text in PDF www.elis.sk Keywords: pharmacogenetics, pharmacogenomics, psychiatry, personalized treatment, Slovakia, perspective.
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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