Critical risk factors analysis of infection-associated hemophagocytic lymphohistiocytosis in children

IF 2.4 3区 医学 Q2 HEMATOLOGY Annals of Hematology Pub Date : 2024-11-04 DOI:10.1007/s00277-024-06058-3
Gailing Hao, Wenjin Geng, Chunzhen Li, Quanheng Li, Nan Zhang, Lian Jiang
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儿童感染相关性嗜血细胞淋巴组织细胞增多症的关键风险因素分析。
分析儿童感染相关性嗜血细胞淋巴组织细胞增生症(HLH)的关键因素,为临床医生评估病情、制定治疗方案和改善预后提供理论依据。本研究为回顾性分析。根据是否存在多器官功能障碍综合征(MODS)将60例感染相关HLH患儿分为危重组和非危重组,分析两组患儿的临床特征和实验室数据。采用多因素Logistic回归分析模型评估影响感染相关性HLH患儿危重症的独立危险因素,并采用接收者操作特征曲线(ROC)分析评估危险因素对感染相关性HLH患儿危重症的预测价值。危重组HLH患儿的发病年龄较小。危重组的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、γ-谷氨酰转移酶(GGT)、D-二聚体(DD)和甘油三酯(TG)显著升高,而白蛋白(ALB)显著降低,差异有统计学意义(P
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来源期刊
Annals of Hematology
Annals of Hematology 医学-血液学
CiteScore
5.60
自引率
2.90%
发文量
304
审稿时长
2 months
期刊介绍: Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.
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