Effects of a combination of dyslipidemia and hypertension on the glycemic control of patients with type 2 diabetes mellitus: a cross-sectional study.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL SAGE Open Medicine Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.1177/20503121241265066
Heqing Lou, Yixue Jiang, Chunrong Xu, Zong-Mei Dong, De Liu, Cheng Qiao, Pan Zhang
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Abstract

Objectives: Both dyslipidemia and hypertension contribute to poor glycemic control in patients with type 2 diabetes mellitus, but the combined effect of dyslipidemia and hypertension on glycemic control in patients with type 2 diabetes mellitus has not been evaluated. The aim of this study was to analyze the interaction effect between dyslipidemia and hypertension on glycemic control in patients with type 2 diabetes mellitus.

Methods: A total of 2485 patients with type 2 diabetes mellitus were selected from the Xuzhou community of China by multi-stage cluster random sampling for a cross-sectional survey. Their glycated hemoglobin, dyslipidemia, and hypertension were assessed, and the interaction effects between dyslipidemia and hypertension on glycemic control were analyzed using relative excess risk due to the interaction, the synergy index, and the attributable proportion of the additive interaction.

Results: Of the participants, 62.13% (1544/2485) had dyslipidemia and 55.01% (1367/2485) had hypertension. Of the participants, 76.66% (1905/2485) who had both dyslipidemia and hypertension also had poor glycemic control. The prevalence of poor glycemic control was higher in those with both dyslipidemia and hypertension (odds ratio 2.735, 95% confidence interval 2.117-3.532; p < 0.001) compared with those who had normal blood lipids and without hypertension, after adjustment for confounders. The relative excess risk due to the interaction, the attributable proportion, and the synergy index were 1.077 (95% confidence interval 0.558-1.596), 2.637 (95% confidence interval 1.268-4.006), and 0.394 (95% confidence interval 0.230-0.558), respectively, for the interaction between dyslipidemia and hypertension.

Conclusions: Dyslipidemia and hypertension have an additive interaction on poor glycemic control in patients with type 2 diabetes mellitus.

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合并血脂异常和高血压对 2 型糖尿病患者血糖控制的影响:一项横断面研究。
目的:血脂异常和高血压都会导致2型糖尿病患者血糖控制不佳,但尚未评估血脂异常和高血压对2型糖尿病患者血糖控制的联合影响。本研究旨在分析血脂异常和高血压对 2 型糖尿病患者血糖控制的交互影响:方法:通过多阶段整群随机抽样,从中国徐州社区选取了 2485 名 2 型糖尿病患者进行横断面调查。评估了他们的糖化血红蛋白、血脂异常和高血压的情况,并使用交互作用导致的相对超额风险、协同指数和相加交互作用的归因比例分析了血脂异常和高血压对血糖控制的交互作用:在参与者中,62.13%(1544/2485)患有血脂异常,55.01%(1367/2485)患有高血压。在同时患有血脂异常和高血压的参与者中,76.66%(1905/2485)的人血糖控制不佳。在同时患有血脂异常和高血压的人群中,血糖控制不佳的发生率更高(几率比 2.735,95% 置信区间 2.117-3.532;P 结论:血脂异常和高血压是导致血糖控制不佳的主要原因:血脂异常和高血压对 2 型糖尿病患者血糖控制不佳具有叠加作用。
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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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