Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications

IF 6.5 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Frontiers in Neuroendocrinology Pub Date : 2024-10-01 DOI:10.1016/j.yfrne.2024.101159
Qin Wei , Haiyang Zhang , Haixia Guan , Xuefei Song , Huifang Zhou
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Abstract

Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease, characterized by thyroid function disorder and autoimmune imbalance. Previous studies have demonstrated the decreased quality of life and neuropsychiatric manifestations in AITD patients, including anxiety, depression, cognitive impairment and affective disorder. These problems also plague the euthyroid AITD patients. Advanced neuroimaging techniques were well carried out and employed as an explanatory instrument for the above intriguing phenomenon. In recent years, an increasing number of neuroimaging studies have reported that these neuropsychiatric manifestations are accompanied by significant structural and functional brain alterations in AITD patients, mainly involved in neurocognitive and emotional regions, despite the underlying neurobiological mechanism is still unclear. The existing studies suggest that the potential pathogenesis of the neuropsychiatric manifestations and brain alterations does not depend on a single factor, but may result from a combination of thyroid function dysfunction, metabolic disorders, dysregulated autoimmune and trans-synaptic degeneration.
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自身免疫性甲状腺疾病的大脑改变:神经精神影响、神经影像学见解和神经生物学意义。
自身免疫性甲状腺疾病(AITD)是最常见的器官特异性自身免疫性疾病,以甲状腺功能紊乱和自身免疫失衡为特征。以往的研究表明,自身免疫性甲状腺疾病患者的生活质量下降,并表现出神经精神症状,包括焦虑、抑郁、认知障碍和情感障碍。这些问题也困扰着甲状腺功能正常的AITD患者。先进的神经影像学技术得到了很好的应用,并被用来解释上述耐人寻味的现象。近年来,越来越多的神经影像学研究报告称,AITD 患者的这些神经精神表现伴随着明显的脑结构和功能改变,主要涉及神经认知和情感区域,尽管其潜在的神经生物学机制仍不清楚。现有研究表明,神经精神表现和大脑改变的潜在发病机制并不取决于单一因素,而可能是甲状腺功能障碍、代谢紊乱、自身免疫失调和跨突触变性等综合因素的结果。
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来源期刊
Frontiers in Neuroendocrinology
Frontiers in Neuroendocrinology 医学-内分泌学与代谢
CiteScore
13.30
自引率
6.80%
发文量
62
审稿时长
68 days
期刊介绍: Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.
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