Ferritin and Iron Levels Inversely Associated With Lymphoma Risk: A Mendelian Randomization Study.

IF 1.3 Q4 HEMATOLOGY Journal of hematology Pub Date : 2024-10-01 Epub Date: 2024-10-21 DOI:10.14740/jh1335
Boyuan Wu
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Abstract

Background: Current knowledge on iron's role in lymphoma development is very limited, with studies yielding inconsistent findings. To address this gap, we conducted a rigorous two-sample mendelian randomization study, aiming to elucidate the potential associations between iron storage and the risk of developing lymphoma.

Methods: This study leveraged extensive genetic data derived from a comprehensive genome-wide association study (GWAS) comprising 257,953 individuals. The primary objective was to pinpoint single-nucleotide polymorphisms (SNPs) that are significantly associated with iron storage. Subsequently, this genetic information was analyzed in conjunction with summary-level data pertaining to lymphoma cases and controls, sourced from the IEU open GWAS project, which included a sample size of 3,546 lymphoma cases and 487,257 controls. To evaluate the relationship between iron storage and lymphoma risk, an inverse variance-weighted method with random effects was employed, complemented by rigorous sensitivity analyses.

Results: Genetic predisposition to high ferritin and serum iron status was causally associated with lower odds of lymphoma. Ferritin exhibited an odds ratio (OR) of 0.777 (95% confidence interval (CI): 0.628 - 0.961, P = 0.020), indicating 22.3% reduced odds of lymphoma associated with a one standard deviation increase in ferritin levels. Similarly, serum iron demonstrated an OR of 0.776 (95% CI: 0.609 - 0.989, P = 0.040), corresponding to 22.4% decreased odds of lymphoma for a one standard deviation increase in serum iron.

Conclusions: This study suggests that individuals with genes linked to higher iron storage levels have a lower risk of developing lymphoma, but further research is necessary before making any clinical recommendations.

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铁蛋白和铁水平与淋巴瘤风险成反比:一项孟德尔随机研究。
背景:目前有关铁在淋巴瘤发病中的作用的知识非常有限,研究结果也不一致。为了填补这一空白,我们进行了一项严格的双样本亡羊补牢随机研究,旨在阐明铁储存与淋巴瘤发病风险之间的潜在关联:这项研究利用了从一项全面的全基因组关联研究(GWAS)中获得的大量遗传数据,该研究包括 257953 个个体。主要目的是找出与铁贮存显著相关的单核苷酸多态性(SNPs)。随后,这些遗传信息与来自 IEU 开放式 GWAS 项目(包括 3,546 例淋巴瘤病例和 487,257 例对照)的淋巴瘤病例和对照的汇总数据一起进行了分析。为了评估铁储存与淋巴瘤风险之间的关系,我们采用了随机效应的反方差加权法,并辅以严格的敏感性分析:结果:高铁蛋白和血清铁状态的遗传易感性与较低的淋巴瘤发病几率存在因果关系。铁蛋白的几率比(OR)为 0.777(95% 置信区间(CI):0.628 - 0.961,P = 0.020),表明铁蛋白水平每增加一个标准差,患淋巴瘤的几率就会降低 22.3%。同样,血清铁的OR值为0.776(95% CI:0.609 - 0.989,P = 0.040),血清铁每增加一个标准差,患淋巴瘤的几率就会降低22.4%:这项研究表明,具有与较高铁储存水平相关基因的个体患淋巴瘤的风险较低,但在提出任何临床建议之前,有必要进行进一步研究。
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来源期刊
Journal of hematology
Journal of hematology HEMATOLOGY-
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发文量
29
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