Novel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review.

IF 3.1 Q2 PHARMACOLOGY & PHARMACY Advanced pharmaceutical bulletin Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.34172/apb.2024.059
Yahya Yahyavi, Niloufar Kheradi, Abbas Karimi, Abbas Ebrahimi-Kalan, Fatemeh Ramezani, Soudabe Yousefi, Shirin Teymouri Nobari, Hourieh Sadrekarimi, Mohammad Nouri, Mahdi Edalati
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Abstract

Premature ovarian failure (POF), is a condition characterized by the early decline of ovulation function. POF is a complex disorder that can be caused by various factors, and the idiopathic form represents a significant proportion of POF patients. Hormone replacement therapy (HRT) is currently considered the first-line treatment for POF. This review aims to provide a comprehensive overview of recent advancements in platelet-rich plasma (PRP), in vitro activation (IVA), stem cell therapy, exosome therapy, microRNAs, and mitochondrial targeting therapies as a promising cell-free therapeutic approach in reproductive medicine. PLT-Exos, a new generation of cells, has been used to treat POF for more than a decade and has been shown to attenuate oocyte morphology and promote the differentiation of theca cells through the upregulation of PI3K/Akt and Bcl2, as well as the downregulation of the Smad and Bax signaling pathways. This review summarizes the current state of the art in the field of PLT-Exos and discusses the advantages and limitations of their potential clinical applications.

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无细胞疗法治疗卵巢早衰(POF)的新进展:全面回顾。
卵巢早衰(POF)是一种以排卵功能提前衰退为特征的疾病。POF是一种复杂的疾病,可由多种因素引起,特发性POF患者占相当大的比例。激素替代疗法(HRT)目前被认为是治疗 POF 的一线疗法。本综述旨在全面综述富血小板血浆(PRP)、体外激活(IVA)、干细胞疗法、外泌体疗法、微RNA和线粒体靶向疗法作为生殖医学领域一种前景广阔的无细胞疗法的最新进展。PLT-Exos是新一代细胞,用于治疗POF已有十多年的历史,研究表明它能通过上调PI3K/Akt和Bcl2以及下调Smad和Bax信号通路,减弱卵母细胞形态并促进theca细胞分化。本综述总结了PLT-Exos领域的技术现状,并讨论了其潜在临床应用的优势和局限性。
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来源期刊
Advanced pharmaceutical bulletin
Advanced pharmaceutical bulletin PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
2.80%
发文量
51
审稿时长
12 weeks
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