Melanoma Metabolism: Molecular Mechanisms and Therapeutic Implications in Cutaneous Oncology

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-11-04 DOI:10.1002/cam4.70386

Isabella J. Tan, Aarushi K. Parikh, Bernard A. Cohen

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Abstract

Background

Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and a high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology is its metabolic reprogramming, which supports tumor growth, survival, and therapeutic resistance.

Objective

This review aims to explore the key molecular mechanisms driving metabolic alterations in melanoma and their implications for developing therapeutic strategies.

Methods

A Pubmed search was conducted to analyze literature discussing key mechanisms of the Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, and the tumor microenvironment.

Results

Metabolic reprogramming supports melanoma growth, proliferation, and survival. Understanding these complex metabolic dynamics provides valuable insights for developing targeted therapeutic strategies.

Conclusion

Potential therapeutic interventions aimed at disrupting melanoma metabolism highlight the promise of precision medicine in improving treatment outcomes in cutaneous oncology. By targeting metabolic vulnerabilities, novel treatment approaches could significantly enhance the clinical management and prognosis of melanoma.

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黑色素瘤代谢：皮肤肿瘤学的分子机制和治疗意义》。

背景：黑色素瘤是一种侵袭性很强的皮肤癌，其特点是进展迅速、转移性强，给临床肿瘤学带来了巨大挑战。黑色素瘤生物学的一个关键方面是其代谢重编程，它支持肿瘤的生长、存活和耐药性：本综述旨在探讨驱动黑色素瘤代谢改变的关键分子机制及其对制定治疗策略的影响：方法：对Pubmed进行检索，分析讨论沃伯格效应、线粒体功能障碍、脂质代谢增强、表观遗传修饰和肿瘤微环境等关键机制的文献：代谢重编程支持黑色素瘤的生长、增殖和存活。了解这些复杂的代谢动态为制定靶向治疗策略提供了宝贵的见解：旨在破坏黑色素瘤代谢的潜在治疗干预措施凸显了精准医学在改善皮肤肿瘤治疗效果方面的前景。通过针对新陈代谢的薄弱环节，新型治疗方法可显著改善黑色素瘤的临床管理和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.