Recent Trends in anti-tumor mechanisms and molecular targets of celastrol.

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.99592
Yongping Zhu, Yuqing Meng, Junzhe Zhang, Rui Liu, Shengnan Shen, Liwei Gu, Yin-Kwan Wong, Ang Ma, Xin Chai, Ying Zhang, Yanqing Liu, Jigang Wang
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Abstract

Celastrol, a compound derived from traditional Chinese medicine, has therapeutic effects and has been used to treat inflammation-related diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. However, current reviews lack a comprehensive and systematic summary of the anti-tumor mechanisms and molecular targets of celastrol. For this reason, this paper reviews the anticancer properties of celastrol and the molecular mechanisms underlying its anticancer effects. This paper primarily focuses on the mechanism of action of celastrol in terms of inhibition of cell proliferation and regulation of the cell cycle, regulation of apoptosis and autophagy, inhibition of cell invasion and metastasis, anti-inflammation, regulation of immunotherapy, and angiogenesis. More importantly, the target proteins of celastrol identified by chemical proteomics or other methods are highlighted, providing detailed targets with novel therapeutic potential for anti-tumor treatment. In addition, we describe the side effects and strategies to improve the bioavailability of celastrol. In summary, this paper analyzes celastrol, a natural compound with therapeutic effects and clear targets, aiming to draw more attention from the scientific and pharmacological communities and accelerating its clinical application for the benefit of cancer patients.

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西司他醇的抗肿瘤机制和分子靶点的最新发展趋势。
青蒿素是一种源自传统中药的化合物,具有治疗作用,已被用于治疗炎症相关疾病、癌症、心血管疾病和神经退行性疾病。然而,目前的综述缺乏对青蒿素抗肿瘤机制和分子靶点的全面系统总结。因此,本文综述了青蒿素的抗癌特性及其抗癌作用的分子机制。本文主要从抑制细胞增殖和调控细胞周期、调控细胞凋亡和自噬、抑制细胞侵袭和转移、抗炎、调控免疫治疗和血管生成等方面阐述了青蒿素的作用机制。更重要的是,我们重点介绍了通过化学蛋白质组学或其他方法鉴定出的赛拉司特醇靶蛋白,为抗肿瘤治疗提供了具有新治疗潜力的详细靶点。此外,我们还介绍了西司替罗的副作用和提高其生物利用度的策略。总之,本文分析了具有治疗效果和明确靶点的天然化合物青霉烯醇,旨在引起科学界和药理学界的更多关注,并加快其临床应用,造福癌症患者。
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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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