Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.

IF 2.8 4区 医学 Q1 PEDIATRICS Jornal de pediatria Pub Date : 2024-10-25 DOI:10.1016/j.jped.2024.09.003
Stela Carpini-Dantas, Gil Guerra-Junior, Andréa Trevas Maciel-Guerra, Denise Barbieri Marmo, Tarsis Paiva Vieira, Carolina Paniago Lopes, Maria Tereza Matias Baptista, André Moreno Morcillo, Sofia Helena Valente de Lemos-Marini
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Abstract

Objective: The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.

Methods: This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the "GAMLSS" package of the "R" software was used.

Results: The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.

Conclusion: These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.

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巴西特纳综合征女孩在未使用促生长激素或奥昔诺龙的情况下的生长图表。
目的:为特纳综合征(TS)制定特定的生长图表有助于对生长和体重增加情况进行充分评估,及早诊断合并症,并有助于分析促进生长和青春期的治疗效果。本研究的目的是为巴西一家参考中心的细胞遗传学诊断为 TS 的最大系列患者绘制生长图表:这是一项纵向研究,259例TS患者出生于1957年至2014年,在1975年至2019年期间接受了随访,未使用GH或诺龙。共测量了3160人的身高和2918人的体重,随后计算了身体质量指数(BMI)。数据分析使用了 "R "软件的 "GAMLSS "软件包:平均目标身高为 157.8 厘米(标准差为 5.2;中位数为 160.4 厘米)。TS 患者 20 岁时的平均身高为 145.6 厘米(标准差 5.9;中位数 146.7 厘米)。为 2 至 20 岁的 TS 女孩绘制了身高、体重和 BMI 年龄曲线图:这些生长图表可用于监测 TS 女孩的生长情况,并验证辅助治疗对促进生长的效果。
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来源期刊
Jornal de pediatria
Jornal de pediatria 医学-小儿科
CiteScore
5.60
自引率
3.00%
发文量
93
审稿时长
43 days
期刊介绍: Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.
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